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  • Rabbit Anti-SMARCB1 Recombinant Antibody (clone R06-2C2)

Rabbit Anti-SMARCB1 Recombinant Antibody (clone R06-2C2) (CAT#: VS3-XY3509)

It is a recombinant rabbit antibody targeting the SMARCB1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1), which plays a key role in cell-cycle control and causes cell cycle arrest in G0/G1. The antibody specifically reacts with human, mouse and rat SMARCB1. It has been determined using Western Blot and Immunoprecipitation. The recommended dilutions of Western Blot and Immunoprecipitation is 1/500-1/1000 and 1/20, respectively.


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Specific Inquiry
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  • Gene Expression
  • Datasheet
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  • COA
Subcellular Location
Figure 1 IF staining of human cell line A-431
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/144_B9_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human tonsil
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows nuclear positivity.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_A_4_8_selected.jpg
Figure 3 Testis
Figure 3 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Preleptotene spermatocytes Staining: High Intensity: Strong Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_A_4_6.jpg
Figure 4 Lymph node
Figure 4 Lymph node
(Germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_A_7_8.jpg
Figure 5 Cerebral cortex
Figure 5 Cerebral cortex
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_B_8_5.jpg
Figure 6 Colon
Figure 6 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_A_7_3.jpg
Figure 7 Kidney
Figure 7 Kidney
(Cells in glomeruli Staining: High Intensity: Strong Quantity:>75% Location: Nuclear Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_A_7_5.jpg
Figure 8 Urinary bladder
Figure 8 Urinary bladder
(Urothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/18248/40923_A_4_5.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000099956-SMARCB1

Specifications

  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human, Mouse and Rat SMARCB1
  • Species Reactivity
  • Human, Mouse, Rat
  • Clone
  • R06-2C2
  • Applications
  • WB, IP
  • Related Disease
  • Coffin-Siris Syndrome 3; Rhabdoid Tumor Predisposition Syndrome 1

Product Property

  • Clonality
  • Monoclonal
  • Aggregation
  • < 5%
  • Format
  • Liquid
  • Buffer
  • PBS (pH 7.4), 150 mM NaCl and 50% glycerol
  • Preservative
  • 0.02% sodium azide
  • Storage
  • Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Shipping
  • Ice packs

Applications

  • Application Notes
  • WB: 1/500-1/1000
    IP: 1/20

Target

  • Alternative Names
  • RDT; CSS3; INI1; SNF5; Snr1; BAF47; INI-1; MRD15; RTPS1; Sfh1p; hSNFS; SNF5L1; SWNTS1; PPP1R144
  • Long Name
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  • Cellular Localization
  • Nucleus
  • Post Translation Modifications
  • Ubiquitination at Lys8, Lys292, and Lys324 (NX_Q12824 [NX_Q12824-1])
    Modification sites at PhosphoSitePlus (Q12824)
    Glycosylation from GlyGen (Q12824) 1 site, 1 O-linked glycan (1 site)
  • Function
  • Core component of the BAF (hSWI/SNF) complex.
    This ATP-dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation.
    The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal.
    This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers.
    Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A.

Recommended Products

Isotype Control

Recommended Dilution Buffer

Secondary Antibody

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "SMARCB1"

Recombinant Antibody

CAT Product Name Application Type
MOB-4029z Mouse Anti-SMARCB1 Recombinant Antibody (clone 21H6) WB, ELISA, IHC Mouse IgG1, κ
MOB-1665MZ Recombinant Mouse Anti-Human SMARCB1 Antibody IHC-P, WB Mouse antibody
MRO-1415-CN Recombinant Rabbit Anti-SMARCB1 Monoclonal Antibody (JB49-18) WB, IHC, FC Rabbit IgG
MOB-0057F Mouse Anti-SMARCB1 Recombinant Antibody (MOB-0057F) IHC-P, IF Mouse IgG
VS3-WK311 Rabbit Anti-SMARCB1 Recombinant Antibody (clone JB49-18) WB, ELISA Rabbit IgG

Rabbit Monoclonal Antibody

CAT Product Name Application Type
MOR-3330 Hi-Affi™ Recombinant Rabbit Anti-SMARCB1 Monoclonal Antibody (DS3330AB) WB, IP IgG

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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