Anti-SOD1 (clone W24V206) Recombinant Antibody Coupled Liposome (VS-1024-FY205)
CAT#: VS-1024-FY205
Anti-SOD antibody-conjugated liposomes represent a promising tool for exploring the function of superoxide dismutase (SOD) and the impact of oxidative stress in ischemic heart tissue. By targeting these specific antibodies to SOD, researchers can gain insights into how effectively this enzyme mitigates oxidative damage during ischemic events. This innovative approach has the potential to unveil new therapeutic strategies aimed at enhancing cardiac cell survival and improving outcomes in ischemic heart disease.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IHC staining of human cerebral cortex
Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in glial cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8670/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/30_D2_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/29_D2_1_red_green.jpg
Subcellular Location and Protein Expression
Figure 4 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/31_D2_1_red_green.jpg
Normal Tissue
Figure 5 Cerebral cortex
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_B_9_5.jpg
Normal Tissue
Figure 6 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Nuclear
Peripheral nerve/ganglion
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_7_3.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_7_5.jpg
Normal Tissue
Figure 9 Testis
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Spermatogonia cells
Staining:High
Intensity: Strong
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_4_6.jpg
Normal Tissue
Figure 10 Lymph node
Non-germinal center cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_8_8.jpg
RNA Expression
Figure 11 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142168-SOD1
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More Infomation
Specifications
- Potential Clinical Applications
- Ischemic myocardium in vivo
Product Composition
- Clone
- W24V206
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant mouse monoclonal that was designed to bind selectively to SOD, an essential enzyme that protects cells from oxidative stress. Through its specific binding activity, this antibody can aid researchers in understanding the protective mechanisms SOD provides and its involvement in various diseases linked to oxidative damage. By utilizing this antibody, investigations into the therapeutic potential of modulating SOD activity in conditions like neurodegeneration and cardiovascular diseases can be further advanced.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SOD1
- Introduction
- The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.
- Alternative Names
- Superoxide Dismutase 1; Superoxide Dismutase 1, Soluble; EC 1.15.1.1; HSod1; Amyotrophic Lateral Sclerosis 1 (Adult); Epididymis Secretory Protein Li 44; Superoxide Dismutase, Cystolic; Superoxide Dismutase [Cu-Zn]; Cu/Zn Superoxide Dismutase
- Full Name
- Superoxide Dismutase 1
- Gene ID
- 6647
- UniProt ID
- P00441
- Sequence Similarities
- Belongs to the Cu-Zn superoxide dismutase family.
- Post Translation Modifications
- Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation.
The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
- Protein Refseq
- NP_000445.1
- Function
- Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
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Related Diseases
Amyotrophic Lateral Sclerosis
Downloadable Resources
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Datasheet
MSDS
COA
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