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    Rabbit Anti-SOD1 Recombinant Antibody (VS3-FY2877) (CAT#: VS3-FY2877)

    The anti-SOD1 antibody is a rabbit recombinant monoclonal antibody. It has been specifically designed to target the human SOD1 protein. It cross-reacts with mouse, rat species. This monoclonal antibody proves valuable in disease research related to Spastic Tetraplegia And Axial Hypotonia, Progressive and Amyotrophic Lateral Sclerosis 1. This monoclonal antibody is suitable for employment in Western Blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IHC staining of human cerebral cortex
    Figure 1 IHC staining of human cerebral cortex
    (Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in glial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/8670/ihc_selected.jpg
    Figure 2 IF staining of human cell line A-431
    Figure 2 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/30_D2_1_red_green.jpg
    Figure 3 IF staining of human cell line U-2 OS
    Figure 3 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/29_D2_1_red_green.jpg
    Figure 4 IF staining of human cell line U-251 MG
    Figure 4 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/31_D2_1_red_green.jpg
    Normal Tissue
    Figure 5 Cerebral cortex
    Figure 5 Cerebral cortex
    (Glial cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Nuclear
    Neuropil
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_B_9_5.jpg
    Figure 6 Colon
    Figure 6 Colon
    (Endothelial cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Nuclear
    Peripheral nerve/ganglion
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_7_3.jpg
    Figure 7 Liver
    Figure 7 Liver
    (Cholangiocytes
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Hepatocytes
    Staining:High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_8_4.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Cells in tubules
    Staining:Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_7_5.jpg
    Figure 9 Testis
    Figure 9 Testis
    (Leydig cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Spermatogonia cells
    Staining:High
    Intensity: Strong
    Quantity:>75%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_4_6.jpg
    Figure 10 Lymph node
    Figure 10 Lymph node
    (Non-germinal center cells
    Staining:Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1401/4148_A_8_8.jpg
    RNA Expression
    Figure 11 RNA cell line category: Low cell line specificity
    Figure 11 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000142168-SOD1

    Specifications

    • Host Species
    • Rabbit
    • Type
    • Rabbit IgG
    • Specificity
    • Human, Mouse and Rat SOD1
    • Species Reactivity
    • Human, Mouse, Rat
    • Applications
    • Western Blot, Immunohistochemistry
    • Conjugate
    • Unconjugated, FITC
    • Related Disease
    • Spastic Tetraplegia And Axial Hypotonia, Progressive and Amyotrophic Lateral Sclerosis 1

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/500-1/1000
      Immunohistochemistry: 1/50-1/100

    Target

    • Alternative Names
    • Superoxide Dismutase 1; Superoxide Dismutase 1, Soluble; EC 1.15.1.1; HSod1; Amyotrophic Lateral Sclerosis 1 (Adult); Epididymis Secretory Protein Li 44; Superoxide Dismutase, Cystolic; Superoxide Dismutase [Cu-Zn]; Cu/Zn Superoxide Dismutase
    • Sequence Similarities
    • Belongs to the Cu-Zn superoxide dismutase family.
    • Cellular Localization
    • Cytoplasm
      Mitochondrion
      Nucleus
    • Post Translation Modifications
    • Unlike wild-type protein, the pathogenic variants ALS1 Arg-38, Arg-47, Arg-86 and Ala-94 are polyubiquitinated by RNF19A leading to their proteasomal degradation.
      The pathogenic variants ALS1 Arg-86 and Ala-94 are ubiquitinated by MARCH5 leading to their proteasomal degradation.
      (P00441-SODC_HUMAN)
      The ditryptophan cross-link at Trp-33 is responsible for the non-disulfide-linked homodimerization.
      Such modification might only occur in extreme conditions and additional experimental evidence is required.
      (P00441-SODC_HUMAN)
      Palmitoylation helps nuclear targeting and decreases catalytic activity. (P00441-SODC_HUMAN)
      Succinylation, adjacent to copper catalytic site, probably inhibits activity.
      Desuccinylation by SIRT5 enhances activity.
      (P00441-SODC_HUMAN)
      Glycosylation at Asn87 (NX_P00441 [NX_P00441-1])
      Ubiquitination at Lys10, Lys31, and Lys123 (NX_P00441 [NX_P00441-1])
      Modification sites at PhosphoSitePlus (P00441)
      Glycosylation from GlyConnect SODC_HUMAN (1778)
      Glycosylation from GlyGen (P00441) 2 sites, 2 N-linked glycans (1 site), 1 O-linked glycan (1 site)
    • Function
    • Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Related Resources

    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

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    TAB-465CT Anti-Human SOD1 Single Domain Antibody (TAB-465CT), Research Grade Biosimilar ELISA, WB, IHC, IP Single domain antibody
    MD-ZBF-YC020 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC020) WB, IP, IHC, ELISA Camelid VHH
    MD-ZBF-YC021 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC021) WB, IP, IHC, ELISA Camelid VHH
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    MD-ZBF-YC023 Camelid Anti-SOD1 Recombinant Single Domain Antibody (MD-ZBF-YC023) WB, IP, IHC, ELISA Camelid VHH

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