AbPlus™ Anti-SOST Magnetic Beads (VS-0424-XY2446)

CAT#: VS-0424-XY246

The AbPlus Anti-SOST Magnetic Beads (VS-0424-XY2446) is an innovative affinity resin which is bound with anti-SOST specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of SOST protein under native and denaturing conditions.

Gene Expression
Figure 1 RNA cell line category: Group enriched (HaCaT, SuSa)

Specifications

  • Applications
  • Immunoprecipitation, Protein Purification
  • Matrix
  • Magrose bead (> 50 μmol/mL gel)
  • Bead Ligand
  • Anti-SOST specific antibody
  • Target
  • SOST
  • Immunogen
  • SOST protein
  • Target Species
  • Human
  • Bead Capacity
  • 20-30 mg/mL binding antibody
  • Bead size
  • 10-37 μm
  • Stability
  • pH 2-14
  • Format
  • 20% Suspension
  • Buffer
  • PBS, pH 7.4, with 1% BSA
  • Preservative
  • 0.03% Proclin 300
  • Storage
  • Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

  • Application Notes
  • The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

  • Introduction
  • Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antaggedonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.
  • Alternative Names
  • Sclerostin; Sclerosteosis; DAND6; SOST1; VBCH; CDD
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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