SmartAb™ Recombinant Anti-SOST pH-dependent Antibody (VS-0825-YC314)
CAT#: VS-0825-YC314
The anti-SOST pH-dependent antibody (VS-0825-YC314) is a recombinant monoclonal antibody that exhibits pH-dependent antigen binding to both human and mouse SOST. By introducing histidine mutations that act as a pH-switch, the antibody demonstrates a preferential affinity for SOST under acidic conditions compared to physiological pH. Using a yeast surface display system with a pH-dependent screening pressure, this mAb is identified which shows a significant increase in dissociation from SOST at pH 6.0. This pH-sensitive antibody retains its binding affinity on tumor cells while exhibiting negligible binding to the receptor on normal cells at physiological pH. Human SOST, which encodes the protein sclerostin, is a secreted glycoprotein and a key negative regulator of bone formation. It acts by inhibiting the Wnt signaling pathway and is a therapeutic target for osteoporosis.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (HaCaT, SuSa)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167941-SOST
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Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Human IgG
- Specificity
- Human and Mouse SOST
- Species Reactivity
- Human, Mouse
- Applications
- Neut
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-580CL | Human Anti-SOST Recombinant Antibody (TAB-580CL) | ELISA, WB | Human IgG |
| TAB-411CT | Humanized Anti-SOST Recombinant Antibody (TAB-411CT) | ELISA, Neut | Humanized antibody |
| TAB-411CT-S(P) | Humanized Anti-SOST Recombinant Antibody; scFv Fragment (TAB-411CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-412CT-S(P) | Humanized Anti-SOST Recombinant Antibody; scFv Fragment (TAB-412CT-S(P)) | ELISA, Neut | Humanized scFv |
| TAB-413CT-S(P) | Humanized Anti-SOST Recombinant Antibody; scFv Fragment (TAB-413CT-S(P)) | ELISA, Neut | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-558CL | Afuco™ Anti-SOST Recombinant Antibody (AFC-558CL), ADCC Enhanced | ELISA, WB | Humanized IgG1 |
| AFC-TAB-116 | Afuco™ Anti-SOST Recombinant Antibody (AFC-TAB-116), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | Human IgG1, κ |
| AFC-TAB-115 | Afuco™ Anti-SOST ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-115) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-384CT | Llama Anti-SOST Recombinant Antibody (TAB-384CT) | WB, ELSA, FC | Llama VHH |
| TAB-385CT | Anti-Human SOST Single Domain Antibody (TAB-385CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-386CT | Anti-Human SOST Single Domain Antibody (TAB-386CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-387CT | Anti-Human SOST Single Domain Antibody (TAB-387CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| TAB-388CT | Anti-Human SOST Single Domain Antibody (TAB-388CT), Research Grade Biosimilar | WB, ELSA, FC | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-393CT-S(P) | Anti-Human SOST Recombinant Antibody scFv Fragment (DM4) | ELISA, Neut | Human antibody |
| TAB-394CT-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (TAB-394CT-S(P)) | ELISA, Neut | Human scFv |
| TAB-395CT-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (TAB-395CT-S(P)) | ELISA, Neut | Human scFv |
| TAB-396CT-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (TAB-396CT-S(P)) | ELISA, Neut | Human scFv |
| TAB-397CT-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (TAB-397CT-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1840CT | Recombinant Mouse anti-Human SOST Monoclonal antibody (NN0667-0O24) | WB, ELISA | |
| MOB-012LC | Mouse Anti-SOST Recombinant Antibody (MOB-012LC) | ELISA | Mouse IgG |
| HPAB-1122LY | Human Anti-SOST Recombinant Antibody (HPAB-1122LY) | ELISA | Humanized IgG |
| HPAB-1123LY | Human Anti-SOST Recombinant Antibody (HPAB-1123LY) | ELISA, Block | Humanized IgG |
| HPAB-0920-WJ | Human Anti-SOST Recombinant Antibody (HPAB-0920-WJ) | ELISA | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4434 | Hi-Affi™ Recombinant Rabbit Anti-SOST Monoclonal Antibody (SI527DS) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0461-CN-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0461-CN-S(P)) | ELISA, Block | Human scFv |
| HPAB-0462-CN-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-0462-CN-S(P)) | ELISA, Block | Humanized scFv |
| HPAB-1128-CN-S(P) | Human Anti-SOST Recombinant Antibody (clone Ab1); scFv Fragment | WB, ELISA | Human scFv |
| HPAB-1129-CN-S(P) | Human Anti-SOST Recombinant Antibody (clone Ab2); scFv Fragment | WB, ELISA | Human scFv |
| HPAB-1130-CN-S(P) | Human Anti-SOST Recombinant Antibody (clone Ab3); scFv Fragment | WB, ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-402 | Human Anti-SOST Recombinant Antibody; Fab Fragment (PFBC-402) | IHC, Neut | Human Fab |
| HPAB-1421-FY-S(P) | Rat Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1421-FY-S(P)) | ELISA | Chimeric (mouse/rat) scFv |
| HPAB-1422-FY-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1422-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-1423-FY-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1423-FY-S(P)) | ELISA | Humanized scFv |
| HPAB-1424-FY-S(P) | Human Anti-SOST Recombinant Antibody; scFv Fragment (HPAB-1424-FY-S(P)) | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY246 | AbPlus™ Anti-SOST Magnetic Beads (VS-0424-XY2446) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY180 | Human Anti-SOST scFv-Fc Chimera (VS-0425-FY180) | Inhib, ELISA | Human IgG2, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC297 | Recombinant Anti-SOST Eliminating Antibody, pH-Sensitive (VS-0625-YC297) | Antigen-Sweeping In Vivo. | Mouse IgG4 kappa |
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