Mouse Anti-SOX5 Recombinant Antibody (clone ZN53)
CAT#: VS3-FY1580
This is a mouse IgG3 recombinant monoclonal antibody that demonstrated capability to bind to human SOX5. It is used as a pathological antibody. Pathological antibody, PaAb for short, refers to antibodies produced under pathological conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line SK-MEL-30
Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60499/1262_A4_6_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (AF22, Daudi, HDLM-2, K-562, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134532-SOX5
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG3
- Specificity
- Human SOX5
- Species Reactivity
- Human
- Clone
- ZN53
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- Related Disease
- Lamb-Shaffer Syndrome and Colorectal Cancer
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.3), 1% BSA, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- SRY-Box 5; SRY (Sex Determining Region Y)-Box 5; Transcription Factor SOX-5; SRY Box 5; L-SOX5B; L-SOX5F; L-SOX5; LAMSHF
- Gene ID
- 6660
- UniProt ID
- P35711
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_001248343.1; NP_001248344.1; NP_001317714.1; NP_008871.3; NP_694534.1; NP_821078.1
- Function
- Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SOX5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1911CT | Recombinant Mouse anti-Human SOX5 Monoclonal antibody (8042D7b) | Dot, ICC, IF, WB |
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