Mouse Anti-SOX5 Recombinant Antibody (clone ZN53) (CAT#: VS3-FY1580)
This is a mouse IgG3 recombinant monoclonal antibody that demonstrated capability to bind to human SOX5. It is used as a pathological antibody. Pathological antibody, PaAb for short, refers to antibodies produced under pathological conditions.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line SK-MEL-30
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60499/1262_A4_6_selected.jpg
(Immunofluorescent staining of human cell line SK-MEL-30 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/60499/1262_A4_6_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (AF22, Daudi, HDLM-2, K-562, WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134532-SOX5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000134532-SOX5
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG3
- Specificity
- Human SOX5
- Species Reactivity
- Human
- Clone
- ZN53
- Applications
- Immunohistochemistry-Paraffin
- Conjugate
- Unconjugated
- Related Disease
- Lamb-Shaffer Syndrome and Colorectal Cancer
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.3), 1% BSA, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- SRY-Box 5; SRY (Sex Determining Region Y)-Box 5; Transcription Factor SOX-5; SRY Box 5; L-SOX5B; L-SOX5F; L-SOX5; LAMSHF
- Gene ID
- 6660
- UniProt ID
- P35711
- Cellular Localization
- Nucleus
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_001248343.1; NP_001248344.1; NP_001317714.1; NP_008871.3; NP_694534.1; NP_821078.1
- Function
- Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts. Binds to the proximal promoter region of the myelin protein MPZ gene.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1911CT | Recombinant Mouse anti-Human SOX5 Monoclonal antibody (8042D7b) | Dot, ICC/IF, WB |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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