Anti-SPARCL1 (clone W24V128) Recombinant Antibody Coupled Liposome (VS-1024-FY130)
CAT#: VS-1024-FY130
The anti-SPARCL1 antibody-conjugated liposomes have been studied as a potential targeted drug delivery system for glioma. This system leverages the drug-loading capacity of liposomes and the targeting properties of antibodies, which may enhance the delivery of drugs in the tumor microenvironment, improve treatment efficacy, and reduce side effects.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26225/54191_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26225/54191_A_7_3.jpg
Normal Tissue
Figure 3 Testis
Leydig cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26225/54191_A_4_6.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (AF22, SuSa, U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000152583-SPARCL1
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V128
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was designed to specifically target and bind to human SPARCL1, a protein that plays a crucial role in cellular processes. The specificity of this antibody allows researchers to effectively study the function and regulation of SPARCL1 in various biological contexts. By utilizing this antibody, scientists can gain deeper insights into the pathological implications of SPARCL1 dysregulation in human diseases, potentially paving the way for novel therapeutic approaches.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- SPARCL1
- Introduction
- SPARC-like protein 1 (SPARCL1), also known as hevin, is a secreted protein with high structural similarity to SPARC. SPARCLl (secreted protein acidic and rich inCysteine like 1) is a member of SPARC family, a glycoprotein exocrine to secretory stromal cells, a tumor suppressor molecule that inhibits cell proliferation, invasion and metastasis. Abnormal changes occur in some tumors, and too little secretion promotes the occurrence and development of tumors.
- Alternative Names
- SC1; MAST9; PIG33; MAST 9
- Full Name
- SPARC Like 1
- Gene ID
- 8404
- UniProt ID
- Q14515
- Sequence Similarities
- Belongs to the SPARC family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- N- and O-glycosylated.
O-glycosylated with a core 1 or possibly core 8 glycan.
( Q14515-SPRL1_HUMAN )
Glycosylation at Thr31, Thr40, Ser44, Asn169, Asn176, Asn196, Thr116, Asn280, Thr331, Thr350, Thr398, Asn412, and Asn476 ( NX_Q14515 [NX_Q14515-1] )
Modification sites at PhosphoSitePlus ( Q14515 )
Glycosylation from GlyConnect SPRL1_HUMAN (728)
Glycosylation from GlyGen (Q14515) 19 sites, 12 N-linked glycans (3 sites), 7 O-linked glycans (12 sites)
- Protein Refseq
- NP_001121782.1; NP_001278905.1; NP_001278906.1; NP_004675.3
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0552MZ | Chicken Anti-SPARCL1 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
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| MOR-4436 | Hi-Affi™ Recombinant Rabbit Anti-SPARCL1 Monoclonal Antibody (SI529DS) | ICC, IF, IF | IgG |
| MOR-4437 | Hi-Affi™ Recombinant Rabbit Anti-SPARCL1 Monoclonal Antibody (SI530DS) | FC | IgG |
| MOR-4438 | Hi-Affi™ Recombinant Rabbit Anti-SPARCL1 Monoclonal Antibody (SI531DS) | FC | IgG |
| MOR-4439 | Hi-Affi™ Recombinant Rabbit Anti-SPARCL1 Monoclonal Antibody (SI532DS) | ELISA | IgG |
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