Mouse Anti-SQSTM1 Recombinant Antibody (clone ZN13)
CAT#: VS3-FY1578
This is a pathological antibody, as a mouse recombinant monoclonal antibody that demonstrated capability to target human SQSTM1. Pathological antibody is produced in certain diseases or immune responses. The ZN13 is recommended for dilution of target protein by immunohistochemistry (dilution 1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/64165/1718_H4_8_cr57f3f8bf9c23b_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cytosol & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4587/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows strong nuclear positivity in exocrine glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68843/158940_A_1_3_selected.jpg
Normal Tissue
Figure 4 IHC staining of human stomach
Immunohistochemical staining of human stomach shows strong cytoplasmic and nuclear positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4587/ihc_selected.jpg
Normal Tissue
Figure 5 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4587/151358_A_7_8.jpg
Normal Tissue
Figure 6 Gallbladder
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4587/151358_A_6_4.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000161011-SQSTM1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human SQSTM1
- Species Reactivity
- Human
- Clone
- ZN13
- Applications
- Immunohistochemistry-paraffin
- Conjugate
- Unconjugated
- Related Disease
- Sporadic and familial Paget disease of bone
Product Property
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.3), 1% BSA, 50% glycerol
- Preservative
- 0.02% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Sequestosome 1; Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 KDa; EBI3-Associated Protein Of 60 KDa; Oxidative Stress Induced Like; Ubiquitin-Binding Protein P62; EBIAP; OSIL; P60; Phosphotyrosine Independent Ligand For The Lck SH2 Domain P62; EBI3-Associated Protein P60; Paget Disease Of Bone 3
- Gene ID
- 8878
- UniProt ID
- Q13501
- Cellular Localization
- Cytoplasmic vesicle, autophagosome 5, Preautophagosomal structure 1, Cytoplasm, cytosol 12, Nucleus, PML body 1, Late endosome 2, Lysosome 1, Nucleus 1, Endoplasmic reticulum 1, Cytoplasm, myofibril, sarcome
- Post Translation Modifications
- Acetylation, Isopeptide bond, Lipoprotein, Palmitate, Phosphoprotein, Ubl conjugation
- Protein Refseq
- NP_001135770.1; NP_001135771.1; NP_003891.1
- Function
- Molecular adapter required for selective macroautophagy (aggrephagy) by acting as a a bridge between polyubiquitinated proteins and autophagosomes.
Promotes the recruitment of ubiquitinated cargo proteins to autophagosomes via multiple domains that bridge proteins and organelles in different steps.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "SQSTM1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2420CT | Recombinant Mouse anti-Human SQSTM1 Monoclonal antibody (EML854) | IHC-P, WB, ICC, IF | |
| MRO-2198-CN | Rabbit Anti-SQSTM1 Polyclonal Antibody (MRO-2198-CN) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-QX1050 | Mouse Anti-SQSTM1 Recombinant Antibody (clone 3F8-E6-G9) | WB, IHC, ICC, FC, ELISA | Mouse IgG1 |
| VS3-FY1386 | Recombinant Rabbit Anti-SQSTM1 Antibody (clone R06-9J2) | WB, IHC-Fr, IHC-P, ICC, IF, IP | Rabbit IgG |
| VS7-0425-WR917 | Mouse Anti-SQSTM1 Recombinant Antibody (clone 5H7E2) | WB, IHC, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3403 | Hi-Affi™ Recombinant Rabbit Anti-SQSTM1 Monoclonal Antibody (DS3403AB) | WB, ICC, FC | IgG |
| MOR-4732 | Hi-Affi™ Recombinant Rabbit Anti-SQSTM1 Monoclonal Antibody (TH246DS) | WB, IF, ICC, ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1109 | CytoStream™ Mouse Anti-SQSTM1 Recombinant Antibody (VS13-YC1109) | IHC-P, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY6887 | Anti-SQSTM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6888 | Anti-Mouse SQSTM1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6889 | Anti-Rat SQSTM1 Immunohistochemistry Kit | IHC |
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