AbPlus™ Anti-STAT3 Magnetic Beads (CBACN-530)
CAT#: VS-0424-XY249
The AbPlus Anti-STAT3 Magnetic Beads (CBACN-530) is an innovative affinity resin which is bound with anti-STAT3 specific antibody (CBACN-530). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of STAT3 protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1671/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong nuclear positivity and cytoplasmic in decidual cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1671/155480_A_3_7_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58603/ihc_selected.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68241/153085_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_7_5.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_8_8.jpg
Normal Tissue
Figure 7 Lung
Alveolar cells type I Staining: Medium Intensity: Moderate Quantity: 75%-25% Alveolar cells type I Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Macrophages Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_3_4.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_7_3.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168610-STAT3
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-STAT3 specific antibody (CBACN-530)
- Target
- STAT3
- Immunogen
- Human STAT3 (aa 1-100)
- Target Species
- Human, Mouse, Rat, Zebrafish
- Antibody Clone
- CBACN-530
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
- Alternative Names
- APRF; HIES; ADMIO; ADMIO1
- Gene ID
- 6774
- UniProt ID
- P40763
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Related Diseases
Endometrial Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Throid Cancer
AGE-RAGE Signaling Pathway in Diabetic Complications
Related Signaling Pathways
MAPK Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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| CAT | Product Name | Application | Type |
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| MOB-1395z-S(P) | Recombinant Anti-Human STAT3 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| MOR-0051-FY | Rabbit Anti-STAT3 Recombinant Antibody (clone AFY0022) | ICC, IHC-P, WB | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-113CQ | Llama Anti-STAT3 VHH Single Domain Antibody | WB, IP, FuncS | Llama VHH |
| MOB-092LC | Recombinant Llama Anti-STAT3 VHH Single Domain Antibody | ELISA, FuncS | Llama VHH |
| HPAB-AP506-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP506-YC) | ELISA | Camel VHH |
| HPAB-AP507-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP507-YC) | ELISA | Camel VHH |
| HPAB-AP508-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP508-YC) | ELISA | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX1062 | Mouse Anti-STAT3 Recombinant Antibody (clone 5E9-4D2-10H7) | IHC | Mouse IgG1 |
| VS3-QX1063 | Mouse Anti-STAT3 Recombinant Antibody (clone 2D10-5E10-8H3) | WB, IHC | Mouse IgG1 |
| VS7-0425-WR924 | Mouse Anti-STAT3 Monoclonal Antibody (clone 3B5) | IHC, ICC | Mouse IgG1 |
| VS7-0425-WR926 | Mouse Anti-STAT3 Monoclonal Antibody (VS7-0425-WR926) | WB, IHC-P, IF, ELISA | Mouse IgG |
| VS7-0425-WR927 | Mouse Anti-STAT3 Monoclonal Antibody (VS7-0425-WR927) | WB, IHC-P, IF, ICC, ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY28 | Human Anti-STAT3 scFv-Fc Chimera (VS-0425-FY28) | ELISA, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2195 | Anti-STAT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6951 | Anti-Mouse STAT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6950 | Anti-Human STAT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6953 | Anti-Zebrafish STAT3 Immunohistochemistry Kit | IHC |
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