Mouse Anti-STAT3 Recombinant Antibody (VS3-FY2882)
CAT#: VS3-FY2882
This STAT3 mouse monoclonal antibody is a recombinant monoclonal antibody that has a high affinity for human STAT3 protein. It cross-reacts with mouse, rat, monkey and hamster species. This monoclonal antibody is suitable for employment in Western Blot (1/500-1/1000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1671/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human placenta
Immunohistochemical staining of human placenta shows strong nuclear positivity and cytoplasmic in decidual cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1671/155480_A_3_7_selected.jpg
Normal Tissue
Figure 3 IHC staining of human small intestine
Immunohistochemical staining of human small intestine shows strong positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/58603/ihc_selected.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68241/153085_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Nuclear Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_7_5.jpg
Normal Tissue
Figure 6 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_8_8.jpg
Normal Tissue
Figure 7 Lung
Alveolar cells type I Staining: Medium Intensity: Moderate Quantity: 75%-25% Alveolar cells type I Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Macrophages Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_3_4.jpg
Normal Tissue
Figure 8 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68242/153074_A_7_3.jpg
RNA Expression
Figure 9 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168610-STAT3
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse, Rat, Monkey and Hamster STAT3
- Species Reactivity
- Human, Mouse, Rat, Monkey, Hamster
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- Related Disease
- Autoimmune Disease, Multisystem, Infantile-Onset, 1 and Hyper-Ige Syndrome 1, Autosomal Dominant, With Recurrent Infections
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Signal transducer and activator of transcription 3; Stat3
- Gene ID
- 6774
- UniProt ID
- P40763
- Sequence Similarities
- Belongs to the transcription factor STAT family.
- Cellular Localization
- Cytoplasm
Nucleus
- Post Translation Modifications
- (Microbial infection) Phosphorylated on Tyr-705 in the presence of S.typhimurium SarA. (P40763-STAT3_HUMAN)
Ubiquitination at Lys87, Lys97, Lys177, Lys180, Lys244, Lys294, and Lys709 (NX_P40763 [NX_P40763-1])
Modification sites at PhosphoSitePlus (P40763)
Glycosylation from GlyGen (P40763) 6 sites, 2 O-linked glycans (6 sites)
- Protein Refseq
- XP_047292541.1; XP_047292542.1; XP_054172966.1; XP_054172967.1
- Function
- May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986).
Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225).
Activated by IL31 through IL31RA (PubMed:15194700).
Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(⁺) T-cells into T-helper Th17 or regulatory T-cells (Treg).
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Related Diseases
Endometrial Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Throid Cancer
AGE-RAGE Signaling Pathway in Diabetic Complications
Related Signaling Pathways
MAPK Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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|---|---|---|---|
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| HPAB-M0660-YC-F(E) | Human Anti-STAT3 Recombinant Antibody; Fab Fragment (HPAB-M0660-YC-F(E)) | ELISA | Human Fab |
| HPAB-M0661-YC-F(E) | Human Anti-STAT3 Recombinant Antibody; Fab Fragment (HPAB-M0661-YC-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1395z-S(P) | Recombinant Anti-Human STAT3 Antibody scFv Fragment | ELISA, WB, Neut, FuncS | scFv |
| HPAB-M0660-YC-S(P) | Human Anti-STAT3 Recombinant Antibody; scFv Fragment (HPAB-M0660-YC-S(P)) | ELISA | Human scFv |
| HPAB-M0661-YC-S(P) | Human Anti-STAT3 Recombinant Antibody; scFv Fragment (HPAB-M0661-YC-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
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| MOR-0051-FY | Rabbit Anti-STAT3 Recombinant Antibody (clone AFY0022) | ICC, IHC-P, WB | Rabbit IgG |
| MOR-0053-FY | Rabbit Anti-STAT3 Recombinant Antibody (clone AFY0024) | IHC-P, WB, Inhib | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0660-YC | Human Anti-STAT3 Recombinant Antibody (HPAB-M0660-YC) | ELISA | Human IgG |
| HPAB-M0661-YC | Human Anti-STAT3 Recombinant Antibody (HPAB-M0661-YC) | ELISA | Human IgG |
| ZG-114R | Mouse Anti-STAT3 Recombinant Antibody (ZG-114R) | WB, ELISA, IHC | Mouse IgG |
| ZG-115R | Mouse Anti-STAT3 Recombinant Antibody (ZG-115R) | WB, ELISA, IHC, IF | Mouse IgG |
| ZG-116R | Mouse Anti-STAT3 Recombinant Antibody (ZG-116R) | WB | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP506-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP506-YC) | ELISA | Camel VHH |
| HPAB-AP507-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP507-YC) | ELISA | Camel VHH |
| HPAB-AP508-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP508-YC) | ELISA | Camel VHH |
| HPAB-AP509-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP509-YC) | ELISA, IP, Inhib, Cyt, FuncS | Camel VHH |
| HPAB-AP510-YC | Camel Anti-STAT3 Recombinant Antibody (HPAB-AP510-YC) | ELISA, IP, Inhib, Cyt, FuncS | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY249 | AbPlus™ Anti-STAT3 Magnetic Beads (CBACN-530) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY28 | Human Anti-STAT3 scFv-Fc Chimera (VS-0425-FY28) | ELISA, IF | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2195 | Anti-STAT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6951 | Anti-Mouse STAT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6950 | Anti-Human STAT3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6953 | Anti-Zebrafish STAT3 Immunohistochemistry Kit | IHC |
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