Mouse Anti-SWAP70 Recombinant Antibody (VS3-FY2887)
CAT#: VS3-FY2887
The SWAP70 mouse monoclonal antibody is a recombinant monoclonal antibody that binds to human SWAP70 protein. It cross-reacts with mouse, rat and monkey species. The antibody can be utilized for detection of target protein by Immunoprecipitation (1/20), Western Blot (1/500-1/1000).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & actin filaments.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6929/1972_C1_30_cr5e1498443c5f0_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows strong cytoplasmic positivity in germinal center cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/18798_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/18528_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/18528_A_7_5.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining: Low
Intensity: Moderate
Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/18528_A_4_6.jpg
Normal Tissue
Figure 7 Placenta
Cytotrophoblasts
Staining: High
Intensity: Strong
Quantity:>75%
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Hofbauer cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Syncytiotrophoblasts - cell body
Staining: Medium
Intensity: Moderate
Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/18528_A_1_7.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6810/18528_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (Daudi)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000133789-SWAP70/subcellular
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human, Mouse, Rat, Monkey SWAP70
- Species Reactivity
- Human, Mouse, Rat, Monkey
- Applications
- Western Blot, Immunoprecipitation
- Conjugate
- Unconjugated, FITC
- Related Disease
- Aleutian Mink Disease and B-Cell Lymphoma
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Target
- Alternative Names
- HSPC321; SWAP-70; FLJ39540; KIAA0640
- Gene ID
- 23075
- UniProt ID
- Q9UH65
- Cellular Localization
- Cytoplasm
Cell membrane
Nucleus
Cell projection, lamellipodium
Cytoplasm, cytoskeleton
- Post Translation Modifications
- Tyrosine-phosphorylated. (Q9UH65-SWP70_HUMAN)
Modification sites at PhosphoSitePlus (Q9UH65)
Modification sites at neXtProt (NX_Q9UH65)
Glycosylation from GlyGen (Q9UH65) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_055870.2
- Function
- Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC.
It also mediates signaling of membrane ruffling.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "SWAP70"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2229z | Mouse Anti-SWAP70 Recombinant Antibody (clone 38A4) | WB, ELISA | Mouse IgG1 |
| MOB-2312CT | Recombinant Mouse anti-Human SWAP70 Monoclonal antibody (Z404) | WB, ELISA | |
| ZG-122R | Mouse Anti-SWAP70 Recombinant Antibody (ZG-122R) | WB | Mouse IgG |
| VS3-XY1477 | Mouse Anti-SWAP70 Recombinant Antibody (clone 434CT16.5.5) | WB | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7037 | Anti-SWAP70 Immunohistochemistry Kit | IHC |
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