Mouse Anti-TACR1 Recombinant Antibody (clone 17) (CAT#: FAMAB-0219JF)
Recombinant monoclonal antibody specially binds to the ligand-binding domain of the neurokinin 1 receptor for the neuropeptide substance P. This mouse anti-neurokinin 1 receptor antibody (clone 17) can be useful to treat patients with inflammatory conditions affecting peripheral organs, sunch as skin or eye allergic reactions, arthritis and bronchial asthma.
Specific Inquiry
WB
Figure 1 Substance-P receptor (Tacr1-3) expression and efect of TACR1 antagonist on mast cells.
Expression of Tacr1, Tacr2, and Tacr3 in RPMCs.
Sahid, M. N., Liu, S., Mogi, M., & Maeyama, K. (2020). Tachykinin-1 receptor antagonism suppresses substance-P-and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B3. Inflammation Research, 69(3), 289-298.
Inhib
Figure 2 Effect of TACR1 antagonist on SP and compound-48/80-induced histamine release from RPMCs.
L732138 inhibited low concentration (10 µM) SP-induced histamine release from RPMCs.
Sahid, M. N., Liu, S., Mogi, M., & Maeyama, K. (2020). Tachykinin-1 receptor antagonism suppresses substance-P-and compound 48/80-induced mast cell activation from rat mast cells expressing functional mas-related GPCR B3. Inflammation Research, 69(3), 289-298.
Specifications
- Immunogen
- PS5 (sequence HQSKELLRLGS) conjugate emulsified with Freund's complete adjuvant
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Rat TACR1
- Species Reactivity
- Rat
- Clone
- 17
- Applications
- WB, Inhib
- Related Disease
- Schizophrenia, Migraine, Fibromyalgia
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The TACR1 antibody has been reported in applications of Western Blot, Inhibition.
Target
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone 17"
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2516z | Mouse Anti-TACR1 Recombinant Antibody (clone 35G6) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| FAMAB-0216JF | Mouse Anti-TACR1 Recombinant Antibody (clone 12) | WB, ELISA, IHC | Mouse IgG2a |
| FAMAB-0217JF | Mouse Anti-TACR1 Recombinant Antibody (clone 11) | WB, ELISA, IHC | Mouse IgG3 |
| FAMAB-0218JF | Mouse Anti-TACR1 Recombinant Antibody (clone 6) | WB, IHC | Mouse IgG2a |
| ZG-0007U | Rabbit Anti-TACR1 Recombinant Antibody (clone 1E5) | ELISA, WB | Rabbit IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3490 | Hi-Affi™ Recombinant Rabbit Anti-TACR1 Monoclonal Antibody (DS3490AB) | IP, WB | IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0216JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 12); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
| FAMAB-0217JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 11); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
| FAMAB-0218JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 6); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
| FAMAB-0219JF-F(E) | Mouse Anti-TACR1 Recombinant Antibody (clone 17); Fab Fragment | IHC, ELISA, FuncS | Mouse Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0216JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 12); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
| FAMAB-0217JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 11); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
| FAMAB-0218JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 6); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
| FAMAB-0219JF-S(P) | Mouse Anti-TACR1 Recombinant Antibody (clone 17); scFv Fragment | IHC, ELISA, FuncS | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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