Mouse Anti-TAG72 Recombinant Antibody (clone B72.3) (CAT#: FAMAB-0119-CN)

The murine B72.3 antibody specifically recognizes the tumor-associated TAG72 antigen. The epitope of TAG72 antigen recognized by the B72.3 antibody was defined as NeuAc2-6αGαINAcα1-O-Ser/Thr (sialosyl-Tn).


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ELISA

Figure 1 MAb B72.3 reactivity with carcinomas.

Figure 1 MAb B72.3 reactivity with carcinomas.

Overnight versus30-min primary antibody incubation with formalin-fixed tissue.

Thor, A. , Ohuchi, N. , Szpak, C. A. , Johnston, W. W. , & Schlom, J. . (1986). Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody b72.3. Cancer Research, 46(6), 3118-3124.

IHC

Figure 2 Immunoperoxidase staining offormalin-fixed paraffin-embeddedmalignant tumors using MAb B72.3.

Figure 2 Immunoperoxidase staining offormalin-fixed paraffin-embeddedmalignant tumors using MAb B72.3.

A, invasiveductal carcinoma ofthe breast,metastatic to vesselwithin hepatic triad, strongly reactive. Surrounding hepatic cells, biliary duct, and stroma are nonreactive. x 540. B, metastatic invasive ductal breast carcinoma in bone marrow demonstratescytoplasmic and membranous reactivity. x 540. C, adenocarcinomaof the colon, metastatic to the liver demonstratesgland formationandstrongMAb reactivity.x 330.D, squamouscellcarcinomaof thelung (primary)withheterogeneousstainingreactivity.x 330.E, pancreatic adenocarcinomawith focalcytoplasmicreactivity.x 220.F, gastricadenocarcinoma (signetring histologicaltype)stronglyreactive.x 330.

Thor, A. , Ohuchi, N. , Szpak, C. A. , Johnston, W. W. , & Schlom, J. . (1986). Distribution of oncofetal antigen tumor-associated glycoprotein-72 defined by monoclonal antibody b72.3. Cancer Research, 46(6), 3118-3124.


Specifications

  • Host Species
  • Mouse
  • Derivation
  • Mouse
  • Type
  • Mouse IgG
  • Specificity
  • Human TAG72
  • Species Reactivity
  • Human
  • Clone
  • B72.3
  • Applications
  • WB, ELISA
  • Related Disease
  • Malignant tumor

Product Property

  • Purity
  • >95% as determined by SDS-PAGE and HPLC analysis
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Buffer
  • PBS
  • Preservative
  • No preservatives
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

  • Alternative Names
  • TAG-72; Tumor-associated glycoprotein 72

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

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See other products for "Clone B72.3"

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Mouse Antibody

CAT Product Name Application Type
TAB-723 Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment FuncS, IF, Neut, ELISA, FC, IP, WB Mouse Fab (IgG1, κ)
TAB-H60 Anti-Human TAG-72 Recombinant Antibody (Satumomab) ELISA, FC, IP, FuncS, IF, Neut, ICC IgG1 - kappa
TAB-249 Anti-Human TAG-72 Recombinant Antibody (Minretumomab) WB, FuncS, IF, Neut, ELISA, FC, IP IgG1
TAB-002 Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) IP, IF, FuncS, FC, Neut, ELISA, WB IgG1
PABX-025-S (P) Recombinant Human Anti-TAG-72 Antibody scFv Fragment (B72.3) WB, Neut, FuncS scFv

Immunotoxin

CAT Product Name Application Type
AGTO-L070E anti-TAG72 immunotoxin CC49 (scFv)-PE Cytotoxicity assay, Functional assay

Fc Glycosylation

CAT Product Name Application Type
Gly-016LC Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) ELISA Chimeric antibody (mouse/human)

ADCC Enhanced Antibody

CAT Product Name Application Type
AFC-TAB-249 Afuco™ Anti-TAG72 ADCC Recombinant Antibody (Minretumomab), ADCC Enhanced FuncS, IF, Neut, ELISA, FC ADCC enhanced antibody
AFC-TAB-H60 Afuco™ Anti-TAG72 ADCC Recombinant Antibody (Satumomab), ADCC Enhanced ELISA, FC, IP, FuncS, IF, Neut ADCC enhanced antibody

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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