Provided is a humanized monoclonal antibody designated HuCC49. It is reported that HuCC49 may be potentially useful in both diagnostic and therapeutic clinical trials in patients with TAG-72-positive tumors.
Figure 1 Specificity of humanized antibody CC49 (HuCC49) to TAG-72 antigen.
TAG-72 expression in human colon cancer cells was detected by western blot analysis using the HuCC49 antibody and horseradish peroxidase-conjugated goat anti-human IgG antibody. Lane 1, standard protein markers; lane 2, LS174 T cells (TAG-72-positive); lane 3, WiDr cell extract (TAG-72-negative).
Kim, K. S., Lee, Y. K., Kim, J. S., Koo, K. H., Hong, H. J., & Park, Y. S. (2008). Targeted gene therapy of LS174 T human colon carcinoma by anti-TAG-72 immunoliposomes. Cancer gene therapy, 15(5), 331-340.
Figure 2 Specificity of humanized antibody CC49 (HuCC49) to TAG-72 antigen.
Expression of TAG-72 was monitored by immunofluorescence staining of LS174 T cells using the HuCC49 Fab′ and goat anti-human-FITC-IgG.
Kim, K. S., Lee, Y. K., Kim, J. S., Koo, K. H., Hong, H. J., & Park, Y. S. (2008). Targeted gene therapy of LS174 T human colon carcinoma by anti-TAG-72 immunoliposomes. Cancer gene therapy, 15(5), 331-340.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
---|---|---|---|
TAB-723 | Mouse Anti-TAG72 Recombinant Antibody (clone Anatumomab); Fab Fragment | FuncS, IF, Neut, ELISA, FC, IP, WB | Mouse Fab (IgG1, κ) |
TAB-H60 | Anti-Human TAG-72 Recombinant Antibody (Satumomab) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG1 - kappa |
TAB-249 | Anti-Human TAG-72 Recombinant Antibody (Minretumomab) | WB, FuncS, IF, Neut, ELISA, FC, IP | IgG1 |
TAB-002 | Anti-Human TAG72 Recombinant Antibody (Satumomab Pendetide) | IP, IF, FuncS, FC, Neut, ELISA, WB | IgG1 |
PABX-025-S (P) | Recombinant Human Anti-TAG-72 Antibody scFv Fragment (B72.3) | WB, Neut, FuncS | scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
AGTO-L070E | anti-TAG72 immunotoxin CC49 (scFv)-PE | Cytotoxicity assay, Functional assay |
CAT | Product Name | Application | Type |
---|---|---|---|
PFBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); Fab Fragment | WB, ELISA | Humanized Fab |
FAMAB-0278-YC-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); Fab Fragment | FuncS | Mouse Fab |
FAMAB-0315CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); Fab Fragment | ELISA | Mouse Fab |
FAMAB-0316CQ-F(E) | Human Anti-TAG72 Recombinant Antibody (clone cACT19); Fab Fragment | ELISA | Human Fab |
FAMAB-0317CQ-F(E) | Mouse Anti-TAG72 Recombinant Antibody (clone CC49); Fab Fragment | WB, IP, IF, IHC, FC | Mouse Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
PSBW-119 | Human Anti-TAG72 Recombinant Antibody (clone HuCC49DeltaCH2); scFv Fragment | WB, ELISA | Humanized scFv |
FAMAB-0278-YC-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone nCC49); scFv Fragment | FuncS | Mouse scFv |
FAMAB-0279-YC-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone cCC49); scFv Fragment | FuncS | Mouse scFv |
FAMAB-0315CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19); scFv Fragment | ELISA | Mouse scFv |
FAMAB-0317CQ-S(P) | Mouse Anti-TAG72 Recombinant Antibody (clone CC49); scFv Fragment | WB, IP, IF, IHC, FC | Mouse scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-0285CL | Human Anti-TAG72 Recombinant Antibody (TAB-0285CL) | DB, IHC, BI, SPR | Human IgG |
TAB-0285CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0285CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
TAB-0286CL-S(P) | Human Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-0286CL-S(P)) | DB, IHC, BI, SPR | Human scFv |
TAB-0285CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0285CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
TAB-0286CL-F(E) | Human Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-0286CL-F(E)) | DB, IHC, BI, SPR | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
TAB-505CT | Humanized Anti-TAG72 Recombinant Antibody (TAB-505CT) | WB, ELISA | Humanized antibody |
TAB-505CT-S(P) | Humanized Anti-TAG72 Recombinant Antibody; scFv Fragment (TAB-505CT-S(P)) | WB, ELISA | Humanized scFv |
TAB-505CT-F(E) | Humanized Anti-TAG72 Recombinant Antibody; Fab Fragment (TAB-505CT-F(E)) | WB, ELISA | Humanized Fab |
PABX-025 | Recombinant Human Anti-TAG-72 Antibody (B72.3) | WB, Neut, FuncS, ELISA, Cyt | IgG |
PABX-025-F (E) | Recombinant Human Anti-TAG-72 Antibody Fab Fragment (B72.3 ) | WB, Neut, FuncS | Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
Gly-016LC | Recombinant Anti-Human TAG-72 Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
---|---|---|---|
FAMAB-0315CQ | Mouse Anti-TAG72 Recombinant Antibody (clone ACT19) | IHC | Mouse IgG1, κ |
FAMAB-0316CQ | Human Anti-TAG72 Recombinant Antibody (clone cACT19) | ELISA | Chimeric (mouse/human) IgG1, κ |
FAMAB-0317CQ | Mouse Anti-TAG72 Recombinant Antibody (clone CC49) | WB, IP, IF, IHC, FC | Mouse IgG1, κ |
FAMAB-0119-CN | Mouse Anti-TAG72 Recombinant Antibody (clone B72.3) | WB, ELISA | Mouse IgG |
FAMAB-0120-CN | Human Anti-TAG72 Recombinant Antibody (clone ccM4) | WB, ELISA | Chimeric (mouse/human) IgG1, Κ |
CAT | Product Name | Application | Type |
---|---|---|---|
AFC-TAB-249 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody (Minretumomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-H60 | Afuco™ Anti-TAG72 ADCC Recombinant Antibody (Satumomab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
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