Rabbit Anti-TBX21 Recombinant Antibody (VS13-YC1142) (CAT#: VS13-YC1142)

• Immunogen
• Recombinant human TBX21.

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human TBX21

• Species Reactivity
• Human

• Applications
• IHC-P

• Conjugate
• NONE

• Related Disease
• Asthma; Nasal Polyps; Aspirin Intolerance; Immunodeficiency

• Clonality
• Monoclonal

• Purification
• Affinity Chromatography purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.

• Preservative
• 0.02% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Immunohistochemistry (IHC): 1/100-1/200

• Alternative Names
• T-Box 21; T-Cell-Specific T-Box Transcription Factor T-Bet; Transcription Factor TBLYM; T-Box Protein 21; TBLYM; TBET;

• Gene ID
• 30009

• UniProt ID
• Q9UL17

• Long Name
• T-Box 21

• Cellular Localization
• Nucleus

• Protein Refseq
• NP_037483.1

• Function
• Lineage-defining transcription factor which initiates Th1 lineage development from naive Th precursor cells both by activating Th1 genetic programs and by repressing the opposing Th2 and Th17 genetic programs (PubMed:10761931).
  Activates transcription of a set of genes important for Th1 cell function, including those encoding IFN-gamma and the chemokine receptor CXCR3.
  Induces permissive chromatin accessibilty and CpG methylation in IFNG (PubMed:33296702).
  Activates IFNG and CXCR3 genes in part by recruiting chromatin remodeling complexes including KDM6B, a SMARCA4-containing SWI/SNF-complex, and an H3K4me2-methyltransferase complex to their promoters and all of these complexes serve to establish a more permissive chromatin state conducive with transcriptional activation.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

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