Mouse Anti-TCL1A Recombinant Antibody (clone 2E3A5)
CAT#: VS7-0425-WR959
This product is a mouse IgG1 antibody that binds to human TCL1A. The antibody 2E3A5 recognizes specific amino acid domain of human TCL1A (AA: 10-104) . It can be used for FC assay.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line REH
Immunofluorescent staining of human cell line REH shows localization to nucleoplasm, cytosol & endoplasmic reticulum.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16604/1778_H1_6_selected.jpg
Normal Tissue
Figure 2 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16604/37654_A_9_8.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/16604/37654_A_4_8.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (Daudi, REH, U-698)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000100721-TCL1A
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Specifications
- Immunogen
- Recombinant human TCL1A (AA: 10-104) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human TCL1A
- Species Reactivity
- Human
- Clone
- 2E3A5
- Molecule Class
- Proto-Oncogene
- Applications
- FC
- Conjugate
- Unconjugated
- Related Disease
- Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- TCL1A; Oncogene TCL-1; Oncogene TCL1; T-Cell Lymphoma-1; Protein P14 TCL1; T-Cell Leukemia/Lymphoma Protein 1A; T-Cell Leukemia/Lymphoma 1A
- Gene ID
- 8115
- UniProt ID
- P56279
- Long Name
- TCL1A Gene(Protein Coding) T Cell Leukemia/Lymphoma 1A
- Cellular Localization
- Cytoplasm; Endoplasmic reticulum; Microsome; Nucleus
- Protein Refseq
- NP_001092195.1
- Function
- Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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Reconstitution Buffer
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Recommended Dilution Buffer
- CAT
- Product Name
See other products for "TCL1A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3559z | Mouse Anti-TCL1A Recombinant Antibody (clone 12A10) | WB, FC, IHC, IP | Mouse IgG2a |
| ZG-0112C | Mouse Anti-TCL1A Recombinant Antibody (clone ABT-TCL1) | IHC-P, IF | Mouse IgG |
| ZG-0113C | Mouse Anti-TCL1A Recombinant Antibody (clone PT0243) | IHC-P, IF | Mouse IgG |
| VS3-QX1088 | Mouse Anti-TCL1A Recombinant Antibody (clone 5E-3A) | WB, FC | Mouse IgG1 |
| VS3-FY1433 | Recombinant Mouse Anti-TCL1A Antibody (clone 4A1-8E8-2F9) | IHC-P | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0576MZ | Chicken Anti-TCL1A Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3524 | Rabbit Anti-TCL1A Recombinant Antibody (clone DS3524AB) | FC, ICC, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0167 | APC-A*02:01/Human TCL1 (LLPIMWQL) MHC Tetramer | FCM | |
| MHC-CN0168 | PE-A*02:01/Human TCL1 (LLPIMWQL) MHC Tetramer | FCM | |
| MHC-CN1427 | PE-A*02:01/Human TCL1A (SLLPIMWQL) MHC Tetramer | FCM | |
| MHC-YF289 | A*02:01/Human TCL1 (SLLPIMWQL) MHC Monomer | MHC Multimer |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY204 | CytoStream™ Mouse Anti-TCL1A Recombinant Antibody (VS-0225-XY204) | FC, IF, IHC | Mouse IgG2b, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2260 | Anti-TCL1A Immunohistochemistry Kit | IHC | |
| VS-0525-XY7143 | Anti-Human TCL1A Immunohistochemistry Kit | IHC |
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