Rabbit Anti-TEC Recombinant Antibody (clone R09-6E7) (CAT#: VS3-FY1899)

• Immunogen
• Synthetic peptide of human Tec

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human TEC

• Species Reactivity
• Human

• Clone
• R09-6E7

• Applications
• Western Blot, Immunofluorescence

• MW
• The calculated weight of the target protein is approximately 74 kDa, while the observed molecular weight stands at 58-75 kDa.

• Related Disease
• Transient Erythroblastopenia Of Childhood and Agammaglobulinemia, X-Linked

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunofluorescence: 1/50-1/200

• Alternative Names
• Tec Protein Tyrosine Kinase; EC 2.7.10.2; PSCTK4; Tyrosine-Protein Kinase Tec; EC 2.7.10

• Gene ID
• 7006

• UniProt ID
• P42680

• Sequence Similarities
• Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.

• Cellular Localization
• Cell membrane, Cytoplasm, Cytoskeleton, Membrane

• Post Translation Modifications
• Following B-cell or T-cell receptors engagement, translocates to the plasma membrane where it gets phosphorylated at Tyr-519.
  Undergoes also tyrosine phosphorylation during platelet activation.
  (P42680-TEC_HUMAN)
  Modification sites at PhosphoSitePlus (P42680)
  Modification sites at neXtProt (NX_P42680)

• Protein Refseq
• XP_011512039.1; XP_011512043.2; XP_047272062.1; XP_047272063.1; XP_047272064.1

• Function
• Plays a redundant role to ITK in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. Required for TCR-dependent IL2 gene induction. Phosphorylates DOK1, one CD28-specific substrate, and contributes to CD28-signaling. Mediates signals that negatively regulate IL2RA expression induced by TCR cross-linking. Plays a redundant role to BTK in BCR-signaling for B-cell development and activation, especially by phosphorylating STAP1, a BCR-signaling protein.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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