Mouse Anti-TET2 Recombinant Antibody (VS3-FY2890) (CAT#: VS3-FY2890)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human TET2

• Species Reactivity
• Human

• Applications
• Western Blot, Immunohistochemistry, Immunocytochemistry, Flow cytometry, ELISA

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 223.8 kDa.

• Related Disease
• Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation.
  Has a preference for 5-hydroxymethylcytosine in CpG motifs.
  Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).
  Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation.
  Methylation at the C5 position o

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000
  Immunohistochemistry: 1/50-1/200
  Immunocytochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/200
  ELISA: 1/1000-1/10000

• Alternative Names
• Tet Methylcytosine Dioxygenase 2; KIAA1546; Tet Oncogene Family Member 2; EC 1.14.11.n2; Probable Methylcytosine Dioxygenase TET2; Methylcytosine Dioxygenase TET2; MDS

• Gene ID
• 54790

• UniProt ID
• Q6N021

• Sequence Similarities
• Belongs to the TET family.

• Cellular Localization
• Nucleus
  Chromosome

• Post Translation Modifications
• May be glycosylated.
  Monoubiquitinated at Lys-1299 by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(VprBP) or CUL4A-RBX1-DDB1-DCAF1/VPRBP complex; this modification promotes binding to DNA. (Q6N021-TET2_HUMAN)
  Modification sites at PhosphoSitePlus (Q6N021)
  Modification sites at neXtProt (NX_Q6N021)
  Glycosylation from GlyGen (Q6N021) 9 sites, 1 O-linked glycan (9 sites)

• Protein Refseq
• XP_006714305.1; XP_016863808.1; XP_024309870.1; XP_024309871.1

• Function
• Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in active DNA demethylation.
  Has a preference for 5-hydroxymethylcytosine in CpG motifs.
  Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC).
  Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation.
  Methylation at the C5 position o

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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