Afuco™ Anti-TFPI ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-734)
CAT#: AFC-TAB-734
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant humanized antibody expressed in CHO binding to human TFPI. It is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human smooth muscle
Immunohistochemical staining of human smooth muscle shows distinct positivity in endothelial.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5575/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows distinct cytoplasmic positivity in endothelium.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Endocrine cells Staining: High Intensity: Strong Endothelial cells Staining: High Intensity: Strong Quantity:>75% Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity: 75%-25% Peripheral nerve/ganglion Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_4_6.jpg
Normal Tissue
Figure 6 Placenta
Decidual cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Trophoblastic cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20842/46624_A_2_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (HHSteC, HUVEC TERT2, LHCN-M2, TIME)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000003436-TFPI
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Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Humanized
- Type
- ADCC enhanced antibody
- Species Reactivity
- Human
- Applications
- ELISA, IP, FC, FuncS, Neut, IF
- Conjugate
- Unconjugated
- Generic Name
- Concizumab
- Related Disease
- Hemophilia
Product Property
- Purity
- >95% by SDS-PAGE
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Biosimilar Overview
Please refer to Concizumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Concizumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "concizumab"
Anti-TFPI Recombinant Antibody (Concizumab)Recombinant humanized antibody expressed in CHO binding to human TFPI. Concizumab is a monoclonal IgG4 antibody (mAb) that binds to the Kunitz-type protease inhibitor (KPI) 2 domain of TFPI thereby blocking the interaction of this domain with the active site of FXa.
DrugMonitor™ Anti-Concizumab Antibody (VS-1224-YC301)Concizumab has participated in trials for treating hemophilia A and congenital bleeding disorders. The DrugMonitor™ Anti-Concizumab Antibody (VS-1224-YC301) is an anti-drug antibody (ADA) against Concizumab. This drug-based antibody is raised in mice immunized with the Concizumab. The anti-Concizumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Concizumab in samples.
See other products for "TFPI"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-734 | Anti-TFPI Recombinant Antibody (Concizumab) | ELISA, IP, FC, FuncS, Neut, IF, WB | IgG4 - kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3547 | Rabbit Anti-TFPI Recombinant Antibody (clone DS3547AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0488-CN-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0488-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0489-CN-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-0489-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-2580LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2580LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| HPAB-2581LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2581LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| HPAB-2582LY-S(P) | Human Anti-TFPI Recombinant Antibody; scFv Fragment (HPAB-2582LY-S(P)) | ELISA, WB, FuncS | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0779-CN | Mouse Anti-TFPI Recombinant Antibody (clone 3F18) | ELISA, Neut | Mouse IgG1, κ |
| HPAB-2598LY | Human Anti-TFPI Recombinant Antibody (HPAB-2598LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2599LY | Human Anti-TFPI Recombinant Antibody (HPAB-2599LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2600LY | Human Anti-TFPI Recombinant Antibody (HPAB-2600LY) | ELISA, WB, FuncS | Human IgG |
| HPAB-2601LY | Human Anti-TFPI Recombinant Antibody (HPAB-2601LY) | ELISA, WB, FuncS | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2587LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2587LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2588LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2588LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2589LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2589LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2590LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2590LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| HPAB-2591LY-F(E) | Human Anti-TFPI Recombinant Antibody; Fab Fragment (HPAB-2591LY-F(E)) | ELISA, WB, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC647 | AbPlus™ Anti-TFPI Magnetic Beads (VS-0724-YC647) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-FY189 | Human Anti-TFPI (clone Concizumab) scFv-Fc Chimera | ELISA, FC | Human IgG4, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7198 | Anti-TFPI Immunohistochemistry Kit | IHC |
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