Anti-TFRC (clone W24V47) Recombinant Antibody Coupled Liposome (VS-1024-FY50)
CAT#: VS-1024-FY50
The Anti-TFRC Antibody Liposome is a novel therapeutic formulation designed to target and deliver bioactive compounds specifically to cells expressing the Transferrin Receptor (TFRC). This liposomal delivery system is engineered to enhance the therapeutic efficacy of various therapeutic agents, including small molecules, proteins, or nucleic acids, by leveraging the overexpression of TFRC in certain cancer cells and other pathological conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to endosomes & lysosomes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/28598/546_F8_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/207_B2_1_blue_red_green.jpg
Subcellular Location
Figure 3 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/208_B2_1_blue_red_green.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_9_5.jpg
Normal Tissue
Figure 5 Colon
Glandular cells
Staining:
Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_3.jpg
Normal Tissue
Figure 6 Testis
Leydig cells
Staining:
Medium
Intensity: Strong
Quantity: <25%
Pachytene spermatocytes
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_6_6.jpg
Normal Tissue
Figure 7 Bone marrow
Hematopoietic cells
Staining:
High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_B_6_4.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining:
Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/153/2800_A_8_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HDLM-2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000072274-TFRC
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More Infomation
Specifications
- Potential Clinical Applications
- Traversing the blood-brain barrier (BBB)
- Immunoliposomes Method
- The Tfr antibody were thiolated using a 40:1 molar excess of 2-iminothiolane at room temperature for one hour, following previously described protocols. The resulting thiolated Tfr antibody (OX26-SH) were then combined with PL/pEGFP and PL/pC27 in a weight ratio of peptide to phospholipid of 1:20, and incubated overnight at room temperature. Targeting liposome complexes were subsequently separated using a Sepharose CL-4B column, and eluted with 0.001 M PBS buffer (pH 7.4) from the reaction mixture. The concentration of uncoupled OX26 or Tfr antibody was measured using the NanoOrange Protein Quantitation Kit. The total and uncoupled amounts of Tfr antibody were denoted as C0 and C1, respectively. The coupling efficiency (CE) was calculated using the formula: CE = (1 - C1/C0) × 100%.
Product Composition
- Clone
- W24V47
- Antibody Type
- IgG2a
- Antibody Host
- Mouse
- Antibody Reactivity
- Rat
- Antibody Description
- The mouse anti-rat CD71 antibody, clone OX-26, specifically recognizes rat CD71, commonly referred to as the transferrin receptor. This receptor is a homodimeric type II transmembrane protein found on the surface of all proliferating cells and in cells that have a need for iron, such as reticulocytes and capillary endothelium within the brain. Additionally, clone OX-26 exhibits binding to various non-dividing normal tissues.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TFRC
- Introduction
- This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified.
- Alternative Names
- Transferrin Receptor; TFR1; TRFR; P90; TFR; TR; T9
- Full Name
- Transferrin Receptor
- Gene ID
- 7037
- UniProt ID
- P02786
- Cellular Localization
- Cell membrane, Membrane, Secreted
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G067E | Anti-TFRC immunotoxin HB21 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G067D | Anti-TFRC immunotoxin HB21 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G067G | Anti-TFRC immunotoxin HB21 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G067R | Anti-TFRC immunotoxin HB21 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G067S | Anti-TFRC immunotoxin HB21 (scFv)-Sap | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0464CL | Mouse Anti-TFRC Recombinant Antibody (TAB-0464CL) | FuncS | Mouse IgG |
| TAB-0465CL | Mouse Anti-TFRC Recombinant Antibody (TAB-0465CL) | FuncS | Mouse IgG |
| TAB-0466CL | Mouse Anti-TFRC Recombinant Antibody (TAB-0466CL) | FuncS | Mouse IgG |
| TAB-615CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (6-90) | ELISA, WB, IP | |
| TAB-616CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (55-31) | ELISA, WB, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0467CL | Human Anti-TFRC Recombinant Antibody (TAB-0467CL) | FuncS | Human IgG |
| TAB-619CT-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-619CT-F(E)) | ELISA, WB | Human Fab |
| TAB-620CT-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-620CT-F(E)) | ELISA, WB | Human Fab |
| TAB-621CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (LUCA31) | ELISA, WB, FC | Human antibody |
| TAB-623CT-F(E) | Anti-Human TfR Recombinant Antibody Fab Fragment (3TF12) | WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-611CT | Humanized Anti-TFRC Recombinant Antibody (TAB-611CT) | ELISA | Humanized IgG |
| TAB-611CT-F(E) | Humanized Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-611CT-F(E)) | ELISA | Humanized Fab |
| TAB-612CT-F(E) | Humanized Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-612CT-F(E)) | ELISA | Humanized Fab |
| TAB-613CT-F(E) | Humanized Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-613CT-F(E)) | ELISA | Humanized Fab |
| TAB-614CT-F(E) | Humanized Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-614CT-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-615CT | Anti-Human TfR Recombinant Antibody (6-90) | ELISA, WB, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1999CQ | Rat Anti-Tfrc Recombinant Antibody (clone RI7217) | FC, ICC, IP, WB, Block | Rat IgG2a, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3548 | Rabbit Anti-TFRC Recombinant Antibody (clone DS3548AB) | FC, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC3370 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTGKL) MHC Tetramer | FCM | |
| MHC-LC3371 | PE-DRB1*13:02/Human TFRC (NPGGYVAYSKAATVTG) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0376-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0376-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0377-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0377-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0378-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0378-CN-S(P)) | ELISA, FC | Mouse scFv |
| HPAB-0379-CN-S(P) | Human Anti-TFRC Recombinant Antibody; scFv Fragment (HPAB-0379-CN-S(P)) | ELISA, FC | Humanized scFv |
| HPAB-0380-CN-S(P) | Mouse Anti-TFRC Recombinant Antibody scFv Fragment (HPAB-0380-CN-S(P)) | ELISA, FC, IF, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0376-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0376-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0377-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0377-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0378-CN-F(E) | Mouse Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0378-CN-F(E)) | ELISA, FC | Mouse Fab |
| HPAB-0379-CN-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-0379-CN-F(E)) | ELISA, FC | Humanized Fab |
| HPAB-597-FY-F(E) | Human Anti-TFRC Recombinant Antibody; Fab Fragment (HPAB-597-FY-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2692LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2692LY) | ELISA | Mouse IgG |
| HPAB-2693LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2693LY) | ELISA | Mouse IgG |
| HPAB-2694LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2694LY) | ELISA | Mouse IgG |
| HPAB-2695LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2695LY) | ELISA | Mouse IgG |
| HPAB-2696LY | Mouse Anti-TFRC Recombinant Antibody (HPAB-2696LY) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1481 | AbPlus™ Anti-TFRC Magnetic Beads (VS-0724-YC1481) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY205 | CytoStream™ Mouse Anti-TFRC Recombinant Antibody (clone OX-26) | FC, IHC, IP | Mouse IgG2a, kappa |
| VS-0225-XY206 | CytoStream™ Rat Anti-TFRC Recombinant Antibody (clone RI7217) | FC | Rat IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC571 | Recombinant Anti-TFRC Vesicular Antibody, EV Displayed (VS-0425-YC571) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7200 | Anti-Mouse TFRC Immunohistochemistry Kit | IHC | |
| VS-0525-XY7201 | Anti-Rat TFRC Immunohistochemistry Kit | IHC |
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