Anti-THBD (clone W24V9) Recombinant Antibody Coupled Liposome (VS-1024-FY10) (CAT#: VS-1024-FY10)

• Potential Clinical Applications
• Specific targeting of dendritic cells

• Clone
• W24V9

• Antibody Type
• IgG1

• Antibody Host
• Human

• Antibody Reactivity
• Human

• Antibody Description
• This product is a recombinant human IgG1 antibody that specifically targets thrombomodulin (THBD) and has been purified using affinity chromatography.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• THBD

• Introduction
• The protein encoded by this intronless gene is an endothelial-specific type I membrane receptor that binds thrombin. This binding results in the activation of protein C, which degrades clotting factors Va and VIIIa and reduces the amount of thrombin generated. Mutations in this gene are a cause of thromboembolic disease, also known as inherited thrombophilia.

• Alternative Names
• Thrombomodulin; CD141 Antigen; Fetomodulin; THRM; TM; THPH12; AHUS6; BDCA3; CD141

• Full Name
• Thrombomodulin

• Gene ID
• 7056

• UniProt ID
• P07204

• Cellular Localization
• Membrane

• Post Translation Modifications
• N-glycosylated.
  The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.

• Protein Refseq
• NP_000352.1

• Function
• Thrombomodulin is a specific endothelial cell receptor that forms a 1:1 stoichiometric complex with thrombin. This complex is responsible for the conversion of protein C to the activated protein C (protein Ca). Once evolved, protein Ca scissions the activated cofactors of the coagulation mechanism, factor Va and factor VIIIa, and thereby reduces the amount of thrombin generated.

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