Mouse Anti-TIMD4 Recombinant Antibody (VS3-FY2895) (CAT#: VS3-FY2895)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human TIMD4

• Species Reactivity
• Human

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 41.6 kDa.

• Related Disease
• Histiocytic Sarcoma and Cerebral Malaria

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Alternative Names
• T Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin Mucin Receptor 4; T-Cell Membrane Protein 4; TIMD-4; TIM-4; TIM4; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4; SMUCKLER

• Gene ID
• 91937

• UniProt ID
• Q96H15

• Sequence Similarities
• Belongs to the immunoglobulin superfamily. TIM family.

• Cellular Localization
• Cell membrane
  Single-pass type I membrane protein
  Secreted, extracellular exosome

• Post Translation Modifications
• Glycosylation at Asn291 (NX_Q96H15 [NX_Q96H15-1])
  Modification sites at PhosphoSitePlus (Q96H15)
  Glycosylation from GlyGen (Q96H15) 1 site

• Protein Refseq
• XP_016865510.1; XP_054209765.1; XP_054209766.1; NP_001140198.1

• Function
• Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation.
  Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity).
  Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, 34067457).
  Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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