Mouse Anti-TIMD4 Recombinant Antibody (VS3-FY2895)
CAT#: VS3-FY2895
The anti-TIMD4 antibody has been developed to target human TIMD4 protein, a calculated molecular weight of the protein is about 41.6 kDa. It is recommended for detection of target protein by Flow cytometry (1/50-1/200) and ELISA (1/1000-1/10000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15625/1873_G5_4_selected.jpg
Normal Tissue
Figure 2 IHC staining of human lymph node
Immunohistochemical staining of human lymph node shows distinct positivity in macrophages.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15625/ihc_selected.jpg
Normal Tissue
Figure 3 IHC staining of human tonsil
Immunohistochemical staining of human tonsil shows cytoplasmic positivity in a subset of reaction center cells and lymphoid cells outside reaction centra.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/26027/ihc_selected.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15625/38243_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15625/38243_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity: 75%-25% Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Pachytene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Round or early spermatids Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15625/38243_A_5_6.jpg
RNA Expression
Figure 7 RNA cell line category: Group enriched (U-266/70, U-266/84)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000145850-TIMD4
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| Sub Cat | Applications | Application Notes | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS3-FY2944 | Western Blot, Flow cytometry, ELISA |
Western Blot: 1/500-1/2000 Flow cytometry: 1/50-1/200 ELISA: 1/1000-1/10000 |
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| VS3-FY2896 | Immunocytochemistry, Flow cytometry, ELISA |
Immunocytochemistry: 1/50-1/200 Flow cytometry: 1/50-1/200 ELISA: 1/1000-1/10000 |
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TIMD4
- Species Reactivity
- Human
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 41.6 kDa.
- Related Disease
- Histiocytic Sarcoma and Cerebral Malaria
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- T Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin And Mucin Domain Containing 4; T-Cell Immunoglobulin Mucin Receptor 4; T-Cell Membrane Protein 4; TIMD-4; TIM-4; TIM4; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 4; SMUCKLER
- Gene ID
- 91937
- UniProt ID
- Q96H15
- Sequence Similarities
- Belongs to the immunoglobulin superfamily. TIM family.
- Cellular Localization
- Cell membrane
Single-pass type I membrane protein
Secreted, extracellular exosome
- Post Translation Modifications
- Glycosylation at Asn291 (NX_Q96H15 [NX_Q96H15-1])
Modification sites at PhosphoSitePlus (Q96H15)
Glycosylation from GlyGen (Q96H15) 1 site
- Protein Refseq
- XP_016865510.1; XP_054209765.1; XP_054209766.1; NP_001140198.1
- Function
- Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation.
Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity).
Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, 34067457).
Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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