Mouse Anti-TIMP1 Recombinant Antibody (VS3-CJ224)
CAT#: VS3-CJ224
This product is a mouse antibody that recognizes TIMP1.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/22360/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human prostate
Immunohistochemical staining of human prostate shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/ihc_selected.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_7_5.jpg
Normal Tissue
Figure 4 Prostate
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53417/139501_A_2_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000102265-TIMP1
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Specifications
- Immunogen
- KLH-conjugated synthetic peptide encompassing a sequence within human TIMP1
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human TIMP1
- Species Reactivity
- Human
- Applications
- IHC
- Conjugate
- Unconjugated
Product Property
- Purification
- Immunogen affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.2% BSA, PBS.
- Preservative
- 0.01% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Immunohistochemistry (1:100-1:300).
Target
- Alternative Names
- CLGI; TIMP; Metalloproteinase inhibitor 1; Erythroid-potentiating activity; EPA; Fibroblast collagenase inhibitor; Collagenase inhibitor; Tissue inhibitor of metalloproteinases 1; TIMP-1; EPO; HCI
- Gene ID
- 7076
- UniProt ID
- P01033
- Sequence Similarities
- Belongs to the protease inhibitor I35 (TIMP) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- The activity of TIMP1 is dependent on the presence of disulfide bonds.
N-glycosylated.
- Protein Refseq
- NP_003245.1
- Function
- Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "TIMP1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1378z | Mouse Anti-TIMP1 Recombinant Antibody (clone 39D12) | WB, ELISA | Mouse IgG1 |
| MOB-0859CT | Recombinant Mouse anti-Human TIMP1 Monoclonal antibody (203E2) | ICC, IF, IHC-Fr, IHC-P, WB | |
| ZG-0125C | Mouse Anti-TIMP1 Recombinant Antibody (clone PT2236) | IHC-P, IF | Mouse IgG |
| ZG-0126C | Mouse Anti-TIMP1 Recombinant Antibody (clone ABT-TIMP1) | IHC-P, IF | Mouse IgG |
| VS3-XY1527 | Mouse Anti-TIMP1 Recombinant Antibody (clone 4C2) | WB, IHC, ICC, IF | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-683CT | Anti-Human TIMP-1 Recombinant Antibody (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-683CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-3 ) | ELISA, BL | Human antibody |
| TAB-684CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-28) | ELISA, BL | Human antibody |
| TAB-685CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-1) | ELISA, BL | Human antibody |
| TAB-686CT-F(E) | Anti-Human TIMP-1 Recombinant Antibody Fab Fragment (MS-BW-27) | ELISA, BL | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3575 | Rabbit Anti-TIMP1 Recombinant Antibody (clone DS3575AB) | WB | Rabbit IgG |
| MOR-4458 | Rabbit Anti-TIMP1 Recombinant Antibody (clone SI552DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-LC1976 | PE-B7/Human TIMP1 (APFEPLASGIL) MHC Tetramer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0174-YC-S(P) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); scFv Fragment | ELISA | Human scFv |
| HPAB-0192-WJ-S(P) | Human Anti-TIMP1 Recombinant Antibody; scFv Fragment (HPAB-0192-WJ-S(P)) | ELISA | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0174-YC-F(E) | Human Anti-TIMP1 Recombinant Antibody (clone HuCAL); Fab Fragment | ELISA | Human Fab |
| HPAB-0192-WJ-F(E) | Human Anti-TIMP1 Recombinant Antibody; Fab Fragment (HPAB-0192-WJ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY147 | Human Anti-TIMP1 (clone mab1) scFv-Fc Chimera | ELISA | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7268 | Anti-TIMP1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7269 | Anti-Mouse TIMP1 Immunohistochemistry Kit | IHC |
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