Anti-TIMP3 (clone W24V131) Recombinant Antibody Coupled Liposome (VS-1024-FY133)
CAT#: VS-1024-FY133
Anti-TIM03 antibody-conjugated liposomes have emerged as a novel therapeutic strategy in gliomas, aiming to enhance drug delivery and efficacy by specifically targeting the TIM3 receptors in the tumor microenvironment. This approach leverages the nano-carrier properties of liposomes, which can improve drug biodistribution and increase selectivity for tumor cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/68391/1866_G11_35_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (ASC diff, BJ, BJ hTERT+, fHDF/TERT166, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000100234-TIMP3
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V131
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody specifically designed to bind to human Tissue Inhibitor of Metalloproteinases 3 (TIMP3). TIMP3 is a protein with important biological functions, playing a key role in regulating matrix metalloproteinase activity and extracellular matrix remodeling. The high specificity and sensitivity of this antibody make it a powerful tool for studying TIMP3 and its associated biological processes, providing new research directions for the diagnosis and treatment of related diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TIMP3
- Alternative Names
- TIMP3; Human TIMP3
- Full Name
- TIMP Metallopeptidase Inhibitor 3
- Gene ID
- 7078
- UniProt ID
- P35625
- Sequence Similarities
- Belongs to the protease inhibitor I35 (TIMP) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus ( P35625 )
Modification sites at neXtProt ( NX_P35625 )
Glycosylation from GlyGen (P35625) 1 site, 11 N-linked glycans (1 site)
- Protein Refseq
- NP_000353.1
- Function
- Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.
May form part of a tissue-specific acute response to remodeling stimuli.
Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.
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Datasheet
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COA
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See other products for "TIMP3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2329MZ | Recombinant Mouse Anti-Human TIMP3 Antibody (clone NN0047-8E4) | IHC-P, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7275 | Anti-TIMP3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7276 | Anti-Human TIMP3 Immunohistochemistry Kit | IHC |
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