Rabbit Anti-TJP3 Recombinant Antibody (clone R08-4E8) (CAT#: VS3-FY1942)
This R08-4E8 recombinant monoclonal antibody is specifically engineered to target human TJP3. It cross-reacts with rat. This tight Junction protein ZO 3 antibody was used in western blot analysis of Zonula occludens protein 3 in MCF-7, Caco2 lysates.
Specific Inquiry
WB
Figure 1 Anti-TJP3 Antibody (VS3-FY1942) in WB.
The Zonula occludens protein 3 expression in MCF-7, Caco2 lysates were detected using the anti-Tight Junction Protein ZO 3 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human zonule occludens protein 3
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat TJP3
- Species Reactivity
- Human, Rat
- Clone
- R08-4E8
- Applications
- Western Blot
- MW
- The calculated weight of the target protein is approximately 101 kDa, while the observed molecular weight stands at 140 kDa.
- Related Disease
- Celiac Disease 1
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- Tight Junction Protein 3; Zonula Occludens Protein 3; Zona Occludens Protein 3; ZO3; Tight Junction Protein 3 (Zona Occludens 3); Tight Junction Protein ZO-3; Zona Occludens 3; ZO-3
- Gene ID
- 27134
- UniProt ID
- O95049
- Sequence Similarities
- Belongs to the MAGUK family.
- Cellular Localization
- Cell junction, Cell membrane, Membrane, Nucleus, Tight junction
- Post Translation Modifications
- Phosphorylated (). (O95049-ZO3_HUMAN)
Modification sites at PhosphoSitePlus (O95049)
Modification sites at neXtProt (NX_O95049)
Glycosylation from GlyGen (O95049) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_047294567.1; XP_054176526.1; NP_001254489.1; NP_001254490.1
- Function
- TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton.
The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Rabbit Monoclonal Antibody Products
IgG Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3578 | Rabbit Anti-TJP3 Recombinant Antibody (clone DS3578AB) | WB, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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