What protein does this antibody recognize?

This recombinant Human antibody Fab fragment recognizes TMPRSS4 (Transmembrane Protease, Serine 4). This protein is a member of the serine protease family and is often overexpressed in pancreatic carcinoma.

What applications are recommended for this Fab fragment?

This antibody fragment is recommended for use in Flow Cytometry (FC), Western Blot (WB), and Inhibition (Inhib) assays. It allows for specific targeting of the TMPRSS4 protease in various experimental setups.

Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (HPAB-J0245-YC-F(E))

CAT#: HPAB-J0245-YC-F(E)

This product is a recombinant Human antibody Fab fragment that recognizes TMPRSS4. The antibody was purified by affinity chromatography.

Gene Expression

Normal Tissue Figure 1 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows cytoplasmic positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_4_5_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_B_8_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_7_3.jpg

Normal Tissue Figure 4 Liver

Cholangiocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_7_4.jpg

Normal Tissue Figure 5 Kidney

Cells in glomeruli Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_7_5.jpg

Normal Tissue Figure 6 Testis

Cells in seminiferous ducts Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_6_6.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/6238/17853_A_8_8.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (CAPAN-2, HaCaT, OE19, RPTEC TERT1, RT4)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137648-TMPRSS4

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Specifications

Host Species
Human

Type
Human Fab

Specificity
Human TMPRSS4

Species Reactivity
Human

Applications
FC, WB, Inhib

Product Property

Purity
>95% as determined by SDS-PAGE

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
Transmembrane Protease, Serine 4; Membrane-Type Serine Protease 2; Type II Membrane Serine Protease; Transmembrane Serine Protease 3; Channel-Activating Protease 2; TMPRSS3; MT-SP2

Gene ID
56649

UniProt ID
Q9NRS4

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Breast cancer biomarkers at key points during disease progression

Great For Flow Cytometry

We used this human antibody Fab fragment to analyze TMPRSS4 expression on cell surfaces using flow cytometry. The staining was specific and allowed us to differentiate between expression levels in various carcinoma cell lines. It is a reliable reagent.

Validated For Inhibition

This product was effective in our protease inhibition studies. We also validated its specificity using Western Blot. The recombinant production method and affinity purification resulted in a high-purity product that met all our experimental requirements for studying serine proteases.

Q&As

What protein does this antibody recognize?

A: This recombinant Human antibody Fab fragment recognizes TMPRSS4 (Transmembrane Protease, Serine 4). This protein is a member of the serine protease family and is often overexpressed in pancreatic carcinoma.
What applications are recommended for this Fab fragment?

A: This antibody fragment is recommended for use in Flow Cytometry (FC), Western Blot (WB), and Inhibition (Inhib) assays. It allows for specific targeting of the TMPRSS4 protease in various experimental setups.

View the frequently asked questions answered by Creative Biolabs Support.

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Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-J0245-YC-F(E).pdf

MSDS

MSDS - HPAB-J0245-YC-F(E).pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

See other products for "TMPRSS4"

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CAT	Product Name	Application	Type
TAB-720CT	Human Anti-TMPRSS4 Recombinant Antibody (TAB-720CT)	WB, ELISA	Human antibody

CAT	Product Name	Application	Type
TAB-721CT	Human Anti-TMPRSS4 Recombinant Antibody (TAB-721CT)	WB, ELISA	Human antibody

CAT	Product Name	Application	Type
TAB-722CT	Human Anti-TMPRSS4 Recombinant Antibody (TAB-722CT)	WB, ELISA	Human antibody

CAT	Product Name	Application	Type
TAB-723CT	Anti-Human TMPRSS4 Recombinant Antibody (Ovrll5.A2.1)	ELISA

CAT	Product Name	Application	Type
TAB-724CT	Anti-Human TMPRSS4 Recombinant Antibody (Ovrll5.A51.2)	ELISA

CAT	Product Name	Application	Type
TAB-725CT	Anti-Human TMPRSS4 Recombinant Antibody (Ovrll5.D37.1)	ELISA

CAT	Product Name	Application	Type
TAB-726CT	Anti-Human TMPRSS4 Recombinant Antibody (Ovrll5.A63.2 )	ELISA

CAT	Product Name	Application	Type
TAB-720CT-S(P)	Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (TAB-720CT-S(P))	WB, ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-721CT-S(P)	Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (TAB-721CT-S(P))	WB, ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-723CT-S(P)	Anti-Human TMPRSS4 Recombinant Antibody scFv Fragment (Ovrll5.A2.1)	ELISA

CAT	Product Name	Application	Type
HPAB-J0244-YC	Human Anti-TMPRSS4 Recombinant Antibody (HPAB-J0244-YC)	FC	Human IgG

CAT	Product Name	Application	Type
HPAB-J0245-YC	Human Anti-TMPRSS4 Recombinant Antibody (HPAB-J0245-YC)	FC	Human IgG

CAT	Product Name	Application	Type
HPAB-J0246-YC	Human Anti-TMPRSS4 Recombinant Antibody (HPAB-J0246-YC)	FC	Human IgG

CAT	Product Name	Application	Type
HPAB-J0244-YC-S(P)	Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (HPAB-J0244-YC-S(P))	FC	Human scFv

CAT	Product Name	Application	Type
HPAB-J0245-YC-S(P)	Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (HPAB-J0245-YC-S(P))	FC, WB, Inhib	Human scFv

CAT	Product Name	Application	Type
HPAB-J0246-YC-S(P)	Human Anti-TMPRSS4 Recombinant Antibody; scFv Fragment (HPAB-J0246-YC-S(P))	FC	Human scFv

CAT	Product Name	Application	Type
HPAB-J0244-YC-F(E)	Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (HPAB-J0244-YC-F(E))	FC	Human Fab

CAT	Product Name	Application	Type
HPAB-J0246-YC-F(E)	Human Anti-TMPRSS4 Recombinant Antibody; Fab Fragment (HPAB-J0246-YC-F(E))	FC	Human Fab

CAT	Product Name	Application	Type
VS-0425-YC485	Recombinant Anti-TMPRSS4 Vesicular Antibody, EV Displayed (VS-0425-YC485)	ELISA, FC, Cell-uptake

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