Anti-TNF (clone STI002) Recombinant Antibody Coupled Liposome (VS-1024-FY279)
CAT#: VS-1024-FY279
Anti-TNF-α antibody conjugated liposomes hold significant potential in the treatment of neovascular age-related macular degeneration (nAMD) by selectively targeting and neutralizing tumor necrosis factor alpha, a key mediator in inflammatory processes that contribute to retinal vascular leakage and neovascularization. These liposomes can enhance the localized delivery of therapeutic agents, improving efficacy while minimizing systemic side effects associated with traditional treatments. Additionally, their ability to encapsulate and release multiple drugs in a controlled manner can pave the way for combination therapies that address the complex pathophysiology of nAMD.
Gene Expression
Normal Tissue
Figure 1 Tonsil
Germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78469/168112_A_4_8.jpg
RNA Expression
Figure 2 RNA cell line category: Group enriched (HDLM-2, NB-4)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000232810-TNF
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More Infomation
Specifications
- Potential Clinical Applications
- Neovascular age-related macular degeneration (neovascular AMD), Ulcerative colitis
Product Composition
- Clone
- STI002
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant human monoclonal antibody meticulously developed to recognize and bind to TNF-α (Tumor Necrosis Factor-alpha). Utilizing cutting-edge recombinant methods, this antibody is optimized for high specificity and affinity towards TNF-α, which plays a critical role in inflammatory processes. The ability of this monoclonal antibody to neutralize TNF-α may provide significant benefits in the treatment of autoimmune disorders and chronic inflammatory diseases.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TNF
- Introduction
- This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine.
- Alternative Names
- Tumor Necrosis Factor; Tumor Necrosis Factor Ligand Superfamily Member 2; Cachectin; TNF-Alpha; TNFSF2; TNF-A; TNFA; Tumor Necrosis Factor (TNF Superfamily, Member 2); Tumor Necrosis Factor Ligand 1F
- Full Name
- Tumor Necrosis Factor
- Gene ID
- 7124
- UniProt ID
- P01375
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Post Translation Modifications
- The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
Tumor necrosis factor, soluble form: The soluble form is demyristoylated at Lys-19 and Lys-20 by SIRT6, promoting its secretion.
- Protein Refseq
- NP_000585.2
- Function
- Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Up-regulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918, PubMed:16829952, PubMed:23396208).
Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (By similarity).
Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (PubMed:12794819).
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABL-051 | Recombinant Anti-human TNF VHH Single Domain Antibody | WB, ELISA, IHC, FC, FuncS | Llama VHH |
| HPAB-AP531-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC) | ELISA | Camel VHH |
| HPAB-AP532-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP532-YC) | ELISA | Camel VHH |
| HPAB-AP533-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP533-YC) | ELISA | Camel VHH |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-010 | Anti-Human TNF Recombinant Antibody (TAB-010) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG1, κ |
| TAB-119CQ-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (TAB-119CQ-S(P)) | ELISA, BL | Human scFv |
| TAB-120CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-120CQ-S(P)) | ELISA, Neut | Human antibody |
| TAB-121CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-121CQ-S(P)) | ELISA, Neut | Human antibody |
| TAB-122CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TAB-122CQ-S(P)) | ELISA, Neut | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-006 | Anti-Human TNF Recombinant Antibody (Infliximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-148CQ | Anti-Human TNF Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ | Human Anti-TNF Recombinant Antibody (TAB-402CQ) | ELISA | Chimeric (mouse/human) IgG |
| TAB-148CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-402CQ-F(E)) | ELISA | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-349 | Human Anti-TNF Recombinant Antibody (clone A2); scFv Fragment | WB, ELISA, FuncS | Human scFv |
| HPAB-0046-FY-S(P) | Mouse Anti-TNF Recombinant Antibody (clone 1B7); scFv Fragment | Neut | Mouse scFv |
| HPAB-0675-CN-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0675-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0676-CN-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0676-CN-S(P)) | ELISA, Neut | Human scFv |
| HPAB-0677-CN-S(P) | Human Anti-TNF Recombinant Antibody; scFv Fragment (HPAB-0677-CN-S(P)) | ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111CQ | Anti-Human TNF Recombinant Antibody (B5) | ELISA, WB | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-271CQ | Rabbit Anti-TNF Recombinant Antibody (TAB-271CQ) | ELISA, Neut | Rabbit IgG |
| TAB-112CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (A10G10) | ELISA, WB | |
| TAB-116CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (Vh5/Vk12) | ELISA | |
| TAB-117CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (TAB-117CQ-F(E)) | ELISA | |
| TAB-123CQ-F(E) | Mouse Anti-TNF Recombinant Antibody; Fab Fragment (TAB-123CQ-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-110CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (CDP571) | ELISA | Humanized antibody |
| TAB-114CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-114CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| TAB-115CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-115CQ-F(E)) | ELISA, FC, Neut | Humanized Fab |
| TAB-118CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (TAB-118CQ-F(E)) | ELISA | Humanized antibody |
| TAB-124CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-124CQ-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| Gly-085LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-088LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA, FC | Human antibody |
| Gly-100LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA | Chimeric antibody (mouse/human) |
| Gly-163LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0609MZ | Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2051CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL589) | ELISA, ICC, Neut | Mouse IgG1 |
| NEUT-2052CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL570) | WB, Neut | Mouse IgG2b |
| NEUT-2053CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL571) | WB, Neut | Mouse IgG1 |
| NEUT-2054CQ | Rat Anti-Tnf Recombinant Antibody (NEUT-2054CQ) | Neut | Rat IgG1 |
| NEUT-2055CQ | Rat Anti-Tnf Recombinant Antibody (NEUT-2055CQ) | Neut, FC | Rat IgD |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (NEUT-2057CQ) | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
| NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
| NEUT-2082CQ | Mouse Anti-TNF Recombinant Antibody (clone B-C7) | Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4460 | Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) | ELISA | Rabbit IgG |
| MOR-4461 | Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) | Neut | Rabbit IgG |
| MOR-4465 | Rabbit Anti-TNF Recombinant Antibody (clone SI559DS) | FC | Rabbit IgG |
| MOR-4751 | Rabbit Anti-Tnf Recombinant Antibody (clone TH265DS) | WB | Rabbit IgG |
| MOR-4752 | Rabbit Anti-TNF Recombinant Antibody (clone TH266DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0675-CN | Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0676-CN | Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0677-CN | Human Anti-TNF Recombinant Antibody (HPAB-0677-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0678-CN | Human Anti-TNF Recombinant Antibody (HPAB-0678-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0679-CN | Human Anti-TNF Recombinant Antibody (HPAB-0679-CN) | ELISA, Neut | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0675-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0675-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0676-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0676-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0677-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0677-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0678-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0678-CN-F(E)) | ELISA, Neut | Humanized Fab |
| HPAB-0679-CN-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0679-CN-F(E)) | ELISA, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-768 | Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-768) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-006 | Afuco™ Anti-TNF ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-006) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY256 | AbPlus™ Anti-TNF Magnetic Beads (4H31) | IP, Protein Purification | |
| VS-0724-YC1214 | AbPlus™ Anti-TNF Magnetic Beads (VS-0724-YC1214) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY32 | Human Anti-TNF (clone BPC1500) scFv-Fc Chimera | ELISA, Neut | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY215 | CytoStream™ Mouse Anti-TNF Recombinant Antibody (clone MAb11) | FC | Mouse IgG1, kappa |
| VS-0225-XY216 | CytoStream™ Armenian Hamster Anti-TNF Recombinant Antibody (clone TN3-19.12) | ELISA, FC, Neut, IP, WB | Armenian Hamster IgG |
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