Recombinant Llama Anti-TNF Single Domain Antibody (VHH3) (CAT#: PABC-545)
This product is a recombinant Llama antibody that can recognize TNF. The antibody can antagonize the binding of TNF to its receptor.
Specific Inquiry
FuncS
Figure 1 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.
Bivalent VHH#3 (VHH#3-9GS-VHH#3-9GS-HSA VHH) construct versus PBS control.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.
FuncS
Figure 2 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.
Results for all groups at week 10.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.
Specifications
- Immunogen
- Human TNF
- Host Species
- Llama
- Type
- Llama VHH
- Specificity
- Human TNF
- Species Reactivity
- Human
- Clone
- VHH3
- Applications
- FuncS, ELISA, Neut
- Related Disease
- Arthritis
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for ELISA, Functional Assay, Neutralization. For details, refer to Published Data.
Target
- Alternative Names
- TNF; tumor necrosis factor; TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Asthma
Inflammatory Bowel Diseases
TNF Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNF"
Chimeric Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-006 | Anti-Human TNF Recombinant Antibody (Infliximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-148CQ | Anti-Human TNF Recombinant Antibody | ELISA | Chimeric antibody (mouse/human) |
| TAB-148CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment | ELISA | Chimeric antibody (mouse/human) |
| TAB-402CQ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (TAB-402CQ-S(P)) | ELISA | Mouse scFv |
| TAB-148CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment | ELISA | Chimeric antibody (mouse/human) |
Rat Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-623CL | Bovine Anti-TNF Recombinant Antibody (TAB-623CL) | Neut | Bovine IgG |
Humanized Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-124CQ | Human Anti-TNF Recombinant Antibody (TAB-124CQ) | FuncS, Neut | Humanized antibody |
| TAB-125CQ | Human Anti-TNF Recombinant Antibody (TAB-125CQ) | ELISA, Neut | Humanized antibody |
| TAB-126CQ | Human Anti-TNF Recombinant Antibody (TAB-126CQ) | ELISA, Neut | Humanized antibody |
| TAB-127CQ | Human Anti-TNF Recombinant Antibody (TAB-127CQ) | ELISA, Neut | Humanized antibody |
| TAB-128CQ | Human Anti-TNF Recombinant Antibody (TAB-128CQ) | ELISA, FuncS | Humanized antibody |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-271CQ | Rabbit Anti-TNF Recombinant Antibody (TAB-271CQ) | ELISA, Neut | Rabbit IgG |
| TAB-112CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (A10G10) | ELISA, WB | |
| TAB-116CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (Vh5/Vk12) | ELISA | |
| TAB-117CQ-S(P) | Anti-Human TNF Recombinant Antibody scFv Fragment (TSK114) | ELISA | |
| TAB-271CQ-F(E) | Rabbit Anti-TNF Recombinant Antibody; Fab Fragment (TAB-271CQ-F(E)) | ELISA, WB | Rabbit Fab |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-111CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (B5) | ELISA, WB | Human antibody |
| TAB-113CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-113CQ-F(E)) | ELISA | Human Fab |
| TAB-119CQ-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (TAB-119CQ-F(E)) | ELISA, BL | Human Fab |
| TAB-404CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (BPC1494) | ELISA, WB | Human antibody |
| TAB-405CQ-F(E) | Anti-Human TNF Recombinant Antibody Fab Fragment (XENP6401) | ELISA | Human antibody |
Fc Glycosylation
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
| Gly-085LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-086LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-088LC | Recombinant Anti-Human TNF Antibody (Fc glycosylation) | ELISA, FC | Human antibody |
Non-hyper Galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-083LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Non-hyper galactosylated) | ELISA, FC | Human antibody |
Sialylated IgG Glycan
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-085LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA, FC | Human antibody |
| Gly-163LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Sialylated) | ELISA | Chimeric antibody (mouse/human) |
Hyper-galactosylated
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-086LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
| Gly-087LC-1 | Recombinant Anti-Human TNF Antibody (Fc glycosylation/Hyper-galactosylated) | ELISA, FC | Human antibody |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0229MZ | Recombinant Mouse Anti-Human TNF Antibody (clone G7C6) | ELISA, IHC | Mouse antibody |
| HPAB-0151-YC | Human Anti-TNF Recombinant Antibody (HPAB-0151-YC) | ELISA, Inhib, FuncS | Human IgG |
| HPAB-0046-FY | Mouse Anti-TNF Recombinant Antibody (clone 1B7) | Neut | Mouse IgG |
| HPAB-0675-CN | Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) | ELISA, Neut | Humanized IgG |
| HPAB-0676-CN | Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) | ELISA, Neut | Humanized IgG |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0609MZ | Chicken Anti-Tumor Necrosis Factor-α Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2051CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL589) | ELISA, ICC, Neut | Mouse IgG1 |
| NEUT-2052CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL570) | WB, Neut | Mouse IgG2b |
| NEUT-2053CQ | Mouse Anti-TNF Recombinant Antibody (clone CBL571) | WB, Neut | Mouse IgG1 |
| NEUT-2107CQ | Mouse Anti-TNF Recombinant Antibody (clone TNF104C) | WB, FuncS, ELISA, FC, Neut | Mouse IgG2a |
| NEUT-2108CQ | Mouse Anti-TNF Recombinant Antibody (clone mAb11) | ELISA, CyTOF, FC, ICFC, ICC, IF, IHC, Neut | Mouse IgG1, κ |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2057CQ | Rat Anti-Tnf Recombinant Antibody (clone XT3) | Block, ELISA, IHC, WB | Rat IgG1 |
| NEUT-2070CQ | Mouse Anti-TNF Recombinant Antibody (clone 4F4) | Block, ELISA, ICC, IF, IHC, WB | Mouse IgG1 |
| NEUT-2071CQ | Rabbit Anti-TNF Recombinant Antibody (clone 6E10) | Block, ELISA, IHC, WB | Rabbit IgG1 |
| NEUT-2082CQ | Mouse Anti-TNF Recombinant Antibody (clone B-C7) | Block | Mouse IgG1 |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3602 | Rabbit Anti-Tnf Recombinant Antibody (clone DS3602AB) | ELISA, WB | Rabbit IgG |
| MOR-4460 | Rabbit Anti-TNF Recombinant Antibody (clone SI554DS) | ELISA | Rabbit IgG |
| MOR-4461 | Rabbit Anti-TNF Recombinant Antibody (clone SI555DS) | Neut | Rabbit IgG |
| MOR-4462 | Rabbit Anti-TNF Recombinant Antibody (clone SI556DS) | FC | Rabbit IgG |
| MOR-4463 | Rabbit Anti-TNF Recombinant Antibody (clone SI557DS) | FC | Rabbit IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0151-YC-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0151-YC-F(E)) | ELISA, Inhib, FuncS | Human Fab |
| HPAB-0745LY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-0745LY-F(E)) | ELISA | Chimeric (Mouse/Human) Fab |
| HPAB-0557LY-F(E) | Human Anti-TNF Recombinant Antibody (clone CBL013LY); Fab Fragment | ELISA | Human Fab |
| HPAB-2679LY-F(E) | Mouse Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2679LY-F(E)) | ELISA | Mouse Fab |
| HPAB-2680LY-F(E) | Human Anti-TNF Recombinant Antibody; Fab Fragment (HPAB-2680LY-F(E)) | FC, ELISA | Humanized Fab |
ADCC Enhanced Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-768 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Nerelimomab), ADCC Enhanced | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-006 | Afuco™ Anti-TNF ADCC Recombinant Antibody (Infliximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-010 | Afuco™ Anti-TNF ADCC Recombinant Antibody (AFC-TAB-010), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-AP531-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP531-YC) | ELISA | Camel VHH |
| HPAB-AP532-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP532-YC) | ELISA | Camel VHH |
| HPAB-AP533-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP533-YC) | ELISA | Camel VHH |
| HPAB-AP534-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP534-YC) | ELISA | Camel VHH |
| HPAB-AP535-YC | Camel Anti-TNF Recombinant Antibody (HPAB-AP535-YC) | ELISA | Camel VHH |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-J0247-YC-S(P) | Human Anti-TNF Recombinant Antibody (clone AP024/YC); scFv Fragment | ELISA, FuncS | Human scFv |
| HPAB-J0248-YC-S(P) | Human Anti-TNF Recombinant Antibody (clone F6); scFv Fragment | ELISA, Neut | Human scFv |
| HPAB-1925-FY-F(E) | Mouse Anti-TNF Recombinant Antibody (clone Mab32); scFv Fragment | ELISA | Mouse scFv |
| FAMAB-0332JF-S(P) | Mouse Anti-TNF Recombinant Antibody (clone Di62); scFv Fragment | RIA, ELISA, FuncS | Mouse scFv |
| HPAB-1564WJ-S(P) | Mouse Anti-TNF Recombinant Antibody; scFv Fragment (clone 3B10) | ELISA, WB, Neut | Mouse scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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