Recombinant Llama Anti-TNF Single Domain Antibody (PABC-547) (CAT#: PABC-547)
This product is a recombinant Llama antibody that can recognize TNF. The antibody can antagonize the binding of TNF to its receptor.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
Figure 1 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.
Bivalent VHH#1 (VHH#1-9GS-HSA VHH-9GS-VHH#1) construct versus phosphate-buffered saline (PBS) control.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.
Figure 2 Efficacy of sdAbs in Tg197 mouse model. Human tumor necrosis factor (TNF) transgenic mice were treated at week 3 after birth (one week before arthritic symptoms develop, i.e., in a prophylactic setting) with bivalent anti-TNF/anti-albumin sdAb constructs or etanercept biweekly.
Results for all groups at week 10.
Beirnaert, E., Desmyter, A., Spinelli, S., Lauwereys, M., Aarden, L., Dreier, T., ... & de Haard, H. (2017). Bivalent Llama single-domain antibody fragments against tumor necrosis factor have picomolar potencies due to intramolecular interactions. Frontiers in immunology, 8, 867.
Specifications
- Immunogen
- Human TNF
- Host Species
- Llama
- Type
- Llama VHH
- Specificity
- Human TNF
- Species Reactivity
- Human
- Clone
- PABC-547
- Applications
- FuncS, ELISA, Neut
- Related Disease
- Arthritis
Product Property
- Purity
- >95% as determined by analysis by SDS-PAGE
- Storage
- Store at -20°C for long-term storage. Avoid freeze/thaw cycles.
Applications
- Application Notes
- The antibody was validated for ELISA, Functional Assay, Neutralization. For details, refer to Published Data.
Target
- Alternative Names
- TNF; tumor necrosis factor; TNF; DIF; TNFA; TNFSF2; TNF-alpha; tumor necrosis factor
- Gene ID
- 7124
- UniProt ID
- P01375
Related Resources
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TNF"
Select a product category from the dropdown menu below to view related products.
CAT | Product Name | Application | Type |
---|---|---|---|
MOB-1076z | Mouse Anti-TNF Recombinant Antibody (clone 18C3) | ELISA, FC, FuncS | Mouse IgG1, κ |
HPAB-0151-YC | Human Anti-TNF Recombinant Antibody (HPAB-0151-YC) | ELISA, Inhib, FuncS | Human IgG |
HPAB-0675-CN | Human Anti-TNF Recombinant Antibody (HPAB-0675-CN) | ELISA, Neut | Humanized IgG |
HPAB-0676-CN | Human Anti-TNF Recombinant Antibody (HPAB-0676-CN) | ELISA, Neut | Humanized IgG |
HPAB-0677-CN | Human Anti-TNF Recombinant Antibody (HPAB-0677-CN) | ELISA, Neut | Humanized IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for PABC-547. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IF, IP, Neut, FuncS, ELISA, FC, WB
Application: WB, FuncS, IF, Neut, ELISA, FC, IP
Application: FC, IP, ELISA, Neut, FuncS, IF, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA
Application: FC, IB, Block, Inhib, FuncS, ELISA, FACS, IP, IF
Application: Neut, FC, IHC-Fr, IP, BA
Application: ELISA, Neut
For Research Use Only. Not For Clinical Use.
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.