Human Anti-TNFRSF10B Recombinant Antibody (clone TRA-8)

Name: Human Anti-TNFRSF10B Recombinant Antibody (clone TRA-8)
SKU: HPAB-1180WJ
Rating: 5 (1 reviews)

CAT#: HPAB-1180WJ

This product is a humanized antibody targeting human DR5. This antibody can be used for the treatment of apoptosis-related disease and treatment of dysregulated cell growth.

Published Data Gene Expression

ELISA

Figure 7 Show binding activity of soluble TRAIL and TRA-8 to DR5 and DR4.

ELISA plates were coated with DR5/hIgG1 or DR4/hIgG1 and then incubated with TRAIL or TRA-8.

ELISA

Figure 8 Soluble TRAIL and TRA-8 bind to DR5 and DR4.

ELISA plates were coated with DR5/hIgG1 or DR4/hIgG1 and then incubated with TRAIL or TRA-8.

Figure 9 Shows Flow cytometry analysis of the surface expression of DR5.

Figure 10 T cell lines were incubated with TRA-8 or murine IgG1 isotype control antibody followed by PE-conjugated goat anti-mouse IgG1.

❮

❯

Normal Tissue Figure 1 Cerebral cortex

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

Neuropil
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51170_B_7_5.jpg

Normal Tissue Figure 2 Colon

Endothelial cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Glandular cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_3.jpg

Normal Tissue Figure 3 Liver

Cholangiocytes
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous
Hepatocytes
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_4.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Cells in tubules
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_8_5.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous
Leydig cells
Staining:

High

Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_6_6.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells
Staining:

Medium

Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/23625/51179_A_9_8.jpg

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 7 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120889-TNFRSF10B

❮

❯

Specifications

Immunogen
Recombinant human DR5 protein

Host Species
Human

Derivation
Humanized

Type
Humanized IgG

Specificity
Human DR5

Species Reactivity
Human

Clone
TRA-8

Applications
Cyt, IF, Inhib, WB, ELISA, FC

Related Disease
Apoptosis-related disease

Product Property

Purity
>95% as determined by SDS-PAGE and HPLC analysis

Concentration
Please refer to the vial label for the specific concentration.

Buffer
PBS

Preservative
No preservatives

Storage
Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

Application Notes
The TNFRSF10B antibody has been reported in applications of Cytotoxicity, Immunofluorescence, Inhibition, Western Blot, Enzyme-linked Immunosorbent Assay, Flow Cytometry.
Cyt: 0-1000 ng/ml.
Inhib: 200 μg.

Target

Alternative Names
DR5; CD262; KILLER; TRICK2; TRICKB; ZTNFR9; TRAILR2; TRICK2A; TRICK2B; TRAIL-R2; KILLER/DR5

Gene ID
8795

UniProt ID
O14763

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for HPAB-1180WJ. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - HPAB-1180WJ.pdf

MSDS

MSDS - HPAB-1180WJ.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Clone TRA-8"

CAT
Product Name

See other products for "TNFRSF10B"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
MOB-1172z	Mouse Anti-TNFRSF10B Recombinant Antibody (clone 40C9)	FC, ICC, IHC, IP, FuncS	Mouse IgG1

CAT	Product Name	Application	Type
NABL-052	Recombinant Anti-human TNFRSF10B VHH Single Domain Antibody	WB, ELISA, IHC, FC, FuncS	Llama VHH

CAT	Product Name	Application	Type
TAB-203	Human Anti-TNFRSF10B Recombinant Antibody (TAB-203)	ELISA, IP, FC, FuncS, Neut, IF, ICC	Human IgG1, κ

CAT	Product Name	Application	Type
TAB-196	Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196)	IF, IP, Neut, FuncS, ELISA, FC, ICC	IgG1

CAT	Product Name	Application	Type
TAB-195	Anti-Human TRAIL-R2 Recombinant Antibody (TAB-195)	ELISA, IP, FC, FuncS, Neut, IF, ICC	IgG1 - lambda

CAT	Product Name	Application	Type
TAB-180	Anti-Human DR5 Recombinant Antibody (TAB-180)	FuncS, IF, Neut, ELISA, FC, IP, ICC	IgG1 - lambda

CAT	Product Name	Application	Type
TAB-625CL	Human Anti-TNFRSF10B Recombinant Antibody (TAB-625CL)	ELISA	Single Domain Antibody

CAT	Product Name	Application	Type
PABL-029	Human Anti-TNFRSF10B Recombinant Antibody (PABL-029)	WB, ELISA, FuncS	Human IgG

CAT	Product Name	Application	Type
PABL-030	Human Anti-TNFRSF10B Recombinant Antibody (PABL-030)	WB, ELISA, FuncS	Human IgG

CAT	Product Name	Application	Type
PSBL-029	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment	WB, ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
PSBL-030	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (PSBL-030)	WB, ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
PFBL-029	Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment	WB, ELISA, FuncS	Human Fab

CAT	Product Name	Application	Type
PFBL-030	Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (PFBL-030)	WB, ELISA, FuncS	Human Fab

CAT	Product Name	Application	Type
PABW-057	Human Anti-TNFRSF10B Recombinant Antibody (clone YSd1)	ELISA	Human IgG

CAT	Product Name	Application	Type
PABC-123	Human Anti-TNFRSF10B Recombinant Antibody (clone BDF1)	ELISA	Human IgG

CAT	Product Name	Application	Type
PFBW-057	Human Anti-TNFRSF10B Recombinant Antibody (clone YSd1); Fab Fragment	ELISA	Human Fab

CAT	Product Name	Application	Type
PFBC-123	Human Anti-TNFRSF10B Recombinant Antibody (clone BDF1); Fab Fragment	ELISA	Human Fab

CAT	Product Name	Application	Type
PSBW-057	Human Anti-TNFRSF10B Recombinant Antibody (clone YSd1); scFv Fragment	ELISA	Human scFv

CAT	Product Name	Application	Type
PSBC-123	Human Anti-TNFRSF10B Recombinant Antibody (clone BDF1); scFv Fragment	ELISA	Human scFv

CAT	Product Name	Application	Type
TAB-247MZ	Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-247MZ)	ELISA, FC, FuncS, Inhib	Mouse IgG3, κ

CAT	Product Name	Application	Type
TAB-248MZ	Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-248MZ)	ELISA, FuncS, Inhib	Mouse IgG

CAT	Product Name	Application	Type
TAB-249MZ	Mouse Anti-TNFRSF10B Recombinant Antibody (TAB-249MZ)	ELISA, FuncS, Inhib	Mouse IgG

CAT	Product Name	Application	Type
TAB-250MZ	Human Anti-TNFRSF10B Recombinant Antibody (TAB-250MZ)	FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-251MZ	Human Anti-TNFRSF10B Recombinant Antibody (TAB-251MZ)	FuncS	Humanized IgG

CAT	Product Name	Application	Type
TAB-252MZ	Anti-Human TNFRSF10B Recombinant Antibody	ELISA

CAT	Product Name	Application	Type
TAB-253MZ	Anti-Human TNFRSF10B Recombinant Antibody (AU11)	ELISA, FuncS	Human antibody

CAT	Product Name	Application	Type
TAB-254MZ	Anti-Human TNFRSF10B Recombinant Antibody (AU12)	ELISA, FuncS	Human antibody

CAT	Product Name	Application	Type
TAB-247MZ-S(P)	Mouse Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-247MZ-S(P))	ELISA, WB	Mouse scFv

CAT	Product Name	Application	Type
TAB-250MZ-S(P)	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-250MZ-S(P))	FC, ELISA	Humanized scFv

CAT	Product Name	Application	Type
TAB-251MZ-S(P)	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (TAB-251MZ-S(P))	FC, ELISA	Humanized scFv

CAT	Product Name	Application	Type
MOR-3604	Rabbit Anti-TNFRSF10B Recombinant Antibody (clone DS3604AB), PE	FC, WB	Rabbit IgG

CAT	Product Name	Application	Type
MOR-3605	Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone DS3605AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4468	Rabbit Anti-Tnfrsf10b Recombinant Antibody (clone SI562DS)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4469	Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI563DS)	ELISA, FC	Rabbit IgG

CAT	Product Name	Application	Type
MOR-4473	Rabbit Anti-TNFRSF10B Recombinant Antibody (clone SI567DS)	FC	Rabbit IgG

CAT	Product Name	Application	Type
MOB-104LC	Human Anti-TNFRSF10B Recombinant Antibody (MOB-104LC)	FuncS	Chimeric (mouse/human) IgG1, κ

CAT	Product Name	Application	Type
HPAB-0303-YC-S(P)	Human Anti-TNFRSF10B Recombinant Antibody; scFv Fragment (HPAB-0303-YC-S(P))	ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
HPAB-0303-YC-F(E)	Human Anti-TNFRSF10B Recombinant Antibody; Fab Fragment (HPAB-0303-YC-F(E))	ELISA, FuncS	Humanized Fab

CAT	Product Name	Application	Type
AFC-TAB-196	Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-196)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
AFC-TAB-203	Afuco™ Anti-TNFRSF10B Recombinant Antibody (AFC-TAB-203), ADCC Enhanced	ELISA, IP, FC, FuncS, Neut, IF	Human IgG1, κ

CAT	Product Name	Application	Type
AFC-TAB-180	Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-180)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody

CAT	Product Name	Application	Type
AFC-TAB-195	Afuco™ Anti-TNFRSF10B ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-195)	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-0703-YJ-VHH	Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0703-YJ-VHH)	ELISA, Apop	Camelid VHH

CAT	Product Name	Application	Type
HPAB-0704-YJ-VHH	Camelid Anti-TNFRSF10B Recombinant Single Domain Antibody (HPAB-0704-YJ-VHH)	ELISA	Camelid VHH

CAT	Product Name	Application	Type
VS-0724-XY43	Mouse Anti-TNFRSF10B Agonistic Antibody (VS-0724-XY43)	Agonistic assays	Mouse IgG1

CAT	Product Name	Application	Type
VS-0724-XY44	Mouse Anti-TNFRSF10B Agonistic Antibody (clone B-D37)	ELISA, FC, FuncS, IP	Mouse IgG2b, kappa

CAT	Product Name	Application	Type
VS-0724-XY60	Human Anti-TNFRSF10B Agonistic Antibody (clone AMG 655)	ELISA, Agonistic assays	Human IgG

CAT	Product Name	Application	Type
VS-0125-FY72	Human Anti-TNFRSF10B (clone Lexatumumab) scFv-Fc Chimera	ELISA, IP, FC, FuncS, Neut, IF, ADCC	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0425-YC222	Recombinant Anti-TNFRSF10B Vesicular Antibody, EV Displayed (VS-0425-YC222)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY7361	Anti-Mouse TNFRSF10B Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC232	Recombinant Anti-TNFRSF10B (ECD x DD) Biparatopic Antibody, Tandem scFv	ELISA, FC, ICC, IF, IP, Neut	Tandem scFv

CAT	Product Name	Application	Type
VS-0525-XY7362	Anti-Monkey TNFRSF10B Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0825-YC334	SmartAb™ Recombinant Anti-TNFRSF10B pH-dependent Antibody (VS-0825-YC334)	IF, IP, Neut, ELISA, FC, ICC	Human IgG1

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 2 Anti-Human TNF Antibody (TAB-010) in ELISA

Anti-Human TNF Recombinant Antibody (TAB-010) (CAT# TAB-010)
Application: WB, FC, IP, ELISA, Neut, FuncS, IF

Figure 2 Anti-Human DR5 Recombinant Antibody (TAB-203) in WB

Human Anti-TNFRSF10B Recombinant Antibody (TAB-203) (CAT# TAB-203)
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC

Figure 4 Anti-CD22 Antibody (TAB-198) in Flow Cytometry

Humanized Anti-CD22 Recombinant Antibody (clone Inotuzumab) (CAT# TAB-198)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 2 Anti-Human CSF1R Antibody (TAB-H23) in ELISA

Anti-Human CSF1R Recombinant Antibody (TAB-H23) (CAT# TAB-H23)
Application: WB, ELISA, IP, FC, FuncS, Neut, IF

Figure 2 Anti-EGFR Recombinant Antibody (TAB-710) in ELISA

Anti-EGFR Recombinant Antibody (Nimotuzumab) (CAT# TAB-710)
Application: ELISA, IP, FC, FuncS, Neut, IF, IHC

Figure 2 Anti-S. Aureus Recombinant Antibody (TAB-029) in HPLC

Anti-S. Aureus Recombinant Antibody (TAB-029) (CAT# TAB-029)
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC

Figure 1 Anti-Human Abeta Antibody in SDS-PAGE

Anti-Human Abeta Recombinant Antibody (Solanezumab) (CAT# TAB-228)
Application: WB, FuncS, IF, Neut, ELISA, FC, IP

Figure 1 Anti-Human IL17RA Recombinant Antibody (TAB-217) in SDS-PAGE

Anti-Human IL17RA Recombinant Antibody (TAB-217) (CAT# TAB-217)
Application: WB, ELISA, FC, IP, FuncS, IF, Neut

Figure 2 Anti-Human CD3 Therapeutic Antibody (TAB-019) in WB

Anti-Human CD3 Recombinant Antibody (TAB-019) (CAT# TAB-019)
Application: FC, IP, ELISA, Neut, FuncS, IF, WB

Figure 2 Anti-Human IL6R Antibody (TAB-026) in WB

Anti-Human IL6R Recombinant Antibody (TAB-026) (CAT# TAB-026)
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC

Figure 1 Anti-Human CD19 Recombinant Antibody (TAB-108CL) in ELISA

Anti-Human CD19 Recombinant Antibody (TAB-108CL) (CAT# TAB-108CL)
Application: FC, ADCC, FuncS

Figure 2 Anti-Human GD2 Recombinant Antibody (TAB-304CL) in HPLC

Anti-Human GD2 Recombinant Antibody (hu14.18K322A) (CAT# TAB-304CL)
Application: FC, FuncS

Figure 1 Trastuzumab (TP-083CL) in SPR

Human Anti-ERBB2 Rcombinant Antibody (TP-083CL) (CAT# TP-083CL)
Application:

Figure 1 Anti-histone Antibody-Cytokine Fusion Protein, IgG-IL12 (ACFP-SH113) in ELISA

Anti-histone Antibody-Cytokine Fusion Protein, IgG (NHS76)-IL12 (CAT# ACFP-SH113)
Application:

Figure 2 Anti-Human EGFR Antibody (PABW-088) in DB

Mouse Anti-EGFR Recombinant Antibody (clone 7A7) (CAT# PABW-088)
Application: ELISA, WB

Figure 8 Anti-Influenza A Virus Hemagglutinin H3 HA Recombinant Antibody (MRO-280LC) in DB

Mouse Anti-Influenza A Virus Hemagglutinin H3 HA Recombinant Antibody (MRO-280LC) (CAT# MRO-280LC)
Application: WB, ELISA, IF

Figure 4 Mouse Anti-TNFSF4 Recombinant Antibody (NEUT-2204CQ) in ELISA

Mouse Anti-TNFSF4 Recombinant Antibody (clone R4930) (CAT# NEUT-2204CQ)
Application: FC, Block

Figure 2 Mouse Anti-GDF15 Recombinant Antibody (HPAB-0344-CN) in HPLC

Mouse Anti-GDF15 Recombinant Antibody (HPAB-0344-CN) (CAT# HPAB-0344-CN)
Application: WB, FC, Block

Figure 4 Human Anti-CD3 Recombinant Antibody (HPAB-M0467-YC-S(P)) in FACS

Human Anti-CD3 Recombinant Antibody scFv Fragment (HPAB-M0467-YC-S(P)) (CAT# HPAB-M0467-YC-S(P))
Application: FC

Figure 2 Mouse Anti-His Tag Recombinant Antibody; Fab Fragment (HPAB-0328-WJ-F(E)) in ELISA

Mouse Anti-His Tag Recombinant Antibody; Fab Fragment (HPAB-0328-WJ-F(E)) (CAT# HPAB-0328-WJ-F(E))
Application: ELISA, WB

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.