Anti-TNFRSF1B Recombinant Antibody (VS-0824-YJ45)
CAT#: VS-0824-YJ45
Clone 70 is a mouse IgG2a that binds to an extracellular domain of the C-terminal cysteine loop of the p75 TNF receptor. It may cause a decrease in the rate of TNT dissociation from the receptors. Clone ch32 is a human IgG1 binding to aa 163-179 of human TBP-II. It can inhibit TNF function in this cell without having any inhibitor effect on TNF binding. It has a potential to cause a decrease in the rate of TNT dissociation from the receptors
Gene Expression
Normal Tissue
Figure 1 IHC staining of human stomach
Immunohistochemical staining of human stomach shows positivity in plasma.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/14125_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/13963_A_9_3.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/13963_A_8_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/13963_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/13963_A_6_6.jpg
Normal Tissue
Figure 7 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/4796/13963_A_8_8.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (CAPAN-2, K-562, THP-1, U-87 MG, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000028137-TNFRSF1B
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| Sub Cat | Clone | Host | Applications | Type | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0824-YJ27 | 70 | Mouse | ELISA, WB | Mouse IgG2a kappa | ||||||
| VS-0824-YJ28 | ch32 | Human | ELISA, WB, Inhib | Chimeric (mouse/human) IgG1 kappa |
Specifications
- Immunogen
- Purified TBP-II
- Specificity
- Human TNFRSF1B
- Species Reactivity
- Human
- Related Disease
- Tumor
Product Property
- Purity
- >95% as determined by SDS-PAGE or SEC-HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- p75; TBPII; TNFBR; TNFR2; CD120b; TNFR1B; TNFR80; TNF-R75; p75TNFR; TNF-R-II; tumor necrosis factor receptor superfamily member 1B; TNF-R2; TNF-RII; p75 TNF receptor; p80 TNF-alpha receptor; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II
- Gene ID
- 7133
- UniProt ID
- P15941
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
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Recommended Dilution Buffer
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Reconstitution Buffer
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