Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-144)

Name: Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-144)
SKU: AFC-TAB-144
Rating: 5 (1 reviews)

CAT#: AFC-TAB-144

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD30. It is a human monoclonal antibody used in the treatment of oncological diseases such as relapsed refractory CD30-positive lymphoma including Hodgkin's disease.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line HDLM-2

Immunofluorescent staining of human cell line HDLM-2 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1962_A8_5_selected.jpg

Subcellular Location Figure 2 IHC staining of human testis

Immunohistochemical staining of human testis shows strong cytoplasmic positivity in a subset of cells in seminiferus ducts.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32081/ihc_selected.jpg

Subcellular Location Figure 3 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows leukocyte positivity in germinal center.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/32082/ihc_selected.jpg

Subcellular Location Figure 4 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows cytoplasmic positivity in leukocytes.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/ihc_selected.jpg

Subcellular Location Figure 5 IF staining of human cell line EFO-21

Immunofluorescent staining of human cell line EFO-21 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1907_B6_1_blue_red_green.jpg

Subcellular Location Figure 6 IF staining of human cell line K-562

Immunofluorescent staining of human cell line K-562 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/14823/1993_D10_4_blue_red_green.jpg

Normal Tissue Figure 7 Colon

Endothelial cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_8_3.jpg

Normal Tissue Figure 8 Appendix

Glandular cells
Staining:

Medium

Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/
membranous

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/16/165_A_2_2.jpg

RNA Expression Figure 9 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

RNA Expression Figure 9 RNA cell line category: Cell line enriched (HDLM-2)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000120949-TNFRSF8

❮

❯

Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut

Conjugate
Unconjugated

Generic Name
Iratumumab

Related Disease
Hodgkin's disease (HD)

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
TNFRSF8; tumor necrosis factor receptor superfamily, member 8; CD30, D1S166E; tumor necrosis factor receptor superfamily member 8; KI 1; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30

Gene ID
943

UniProt ID
P28908

REVIEWS AND Q&AS CITATIONS RESOURCES DOWNLOADS RELATED PRODUCTS

Inquiry

Navs

Customer Review

There are currently no Customer reviews or questions for AFC-TAB-144. Click the button above to contact us or submit your feedback about this product.

Submit Your Publication

Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.

Biosimilar Overview

Please refer to Iratumumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Iratumumab.

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-144.pdf

MSDS

MSDS - AFC-TAB-144.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number:

Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Iratumumab"

Anti-Human CD30 Recombinant Antibody (Iratumumab)
Recombinant monoclonal antibody to CD30. Iratumumab is a human monoclonal antibody used in the treatment of oncological diseases such as relapsed refractory CD30-positive lymphoma including Hodgkin's disease.

DrugMonitor™ Anti-Iratumumab Antibody (VS-1224-YC615)
Iratumumab is a human monoclonal antibody used for treating relapsed refractory CD30-positive lymphoma and other oncological diseases. The DrugMonitor™ Anti-Iratumumab Antibody (VS-1224-YC615) is an anti-drug antibody (ADA) against Iratumumab. This drug-based antibody is raised in mice immunized with the Iratumumab. The anti-Iratumumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Iratumumab in samples.

See other products for "TNFRSF8"

Select a product category from the dropdown menu below to view related products.

CAT	Product Name	Application	Type
TAB-144	Anti-Human CD30 Recombinant Antibody (Iratumumab)	ELISA, FC, IP, FuncS, IF, Neut, ICC	IgG1 - kappa

CAT	Product Name	Application	Type
TAB-153	Chimeric (Mouse/Human) Anti-TNFRSF8 Recombinant Antibody (TAB-153)	Neut, ELISA, IF, IP, FuncS, FC, ICC	Human IgG1, κ

CAT	Product Name	Application
AGTO-G062E	Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-PE	Cytotoxicity assay, Function study
AGTO-G062R	Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-RTA	Cytotoxicity assay, Function study
AGTO-G062S	Anti-TNFRSF8 immunotoxin Ki-3 (scFv)-Sap	Cytotoxicity assay, Function study
AGTO-L041E	anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-PE	Cytotoxicity assay, Functional assay
AGTO-L041R	anti-TNFRSF8 immunotoxin Ber-H2 (IgG)-RTA	Cytotoxicity assay, Functional assay

CAT	Product Name	Application	Type
TAB-635CL	Human Anti-TNFRSF8 Recombinant Antibody (TAB-635CL)	ELISA	Human IgG
TAB-103LC	Anti-Human TNFRSF8 Recombinant Antibody	WB, FC, ELISA	Humanized antibody
TAB-103LC-S(P)	Anti-Human TNFRSF8 Recombinant Antibody scFv Fragment	WB, FC, ELISA	Humanized antibody
TAB-103LC-F(E)	Anti-Human TNFRSF8 Recombinant Antibody Fab Fragment	WB, FC, ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-139LC	Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-139LC-1	Recombinant Anti-Human TNFRSF8 Antibody (Fc glycosylation/Non fucosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
BRD-0597MZ	Chicken Anti-TNFRSF8 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-2165CQ	Hamster Anti-Tnfrsf8 Recombinant Antibody (clone mCD30.1)	FC, Stim, Costim, Block	Hamster IgG1

CAT	Product Name	Application	Type
NEUT-2166CQ	Hamster Anti-Tnfrsf8 Recombinant Antibody (clone 2SH12-5F)	Neut, FC	Hamster IgG1, κ

CAT	Product Name	Application	Type
MOR-3617	Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3617AB)	WB, IHC-P	Rabbit IgG
MOR-3618	Rabbit Anti-TNFRSF8 Recombinant Antibody (clone DS3618AB)	ELISA	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0329-YC-F(E)	Mouse Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0329-YC-F(E))	ELISA, FC, Cyt, FuncS	Mouse Fab
HPAB-0330-YC-F(E)	Human Anti-TNFRSF8 Recombinant Antibody; Fab Fragment (HPAB-0330-YC-F(E))	ELISA, FC, Cyt, FuncS	Human Fab
HPAB-1929-FY-S(P)	Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1); Fab Fragment	FC, ELISA	Human Fab
HPAB-1930-FY-S(P)	Human Anti-TNFRSF8 Recombinant Antibody (clone 2H9); Fab Fragment	FC, ELISA	Human Fab
HPAB-1931-FY-S(P)	Human Anti-TNFRSF8 Recombinant Antibody (clone 5F11); Fab Fragment	FC, ELISA	Human Fab

CAT	Product Name	Application	Type
HPAB-0445-CN-S(P)	Mouse Anti-TNFRSF8 Recombinant Antibody (clone T105); scFv Fragment	WB, ELISA, FC	Mouse scFv
HPAB-0447-CN-S(P)	Mouse Anti-TNFRSF8 Recombinant Antibody (clone T405); scFv Fragment	WB, ELISA	Mouse scFv
HPAB-0325CQ-S(P)	Human Anti-TNFRSF8 Recombinant Antibody; scFv Fragment (HPAB-0325CQ-S(P))	ELISA, FC, FuncS, Cyt	Humanized scFv
HPAB-1929-FY-F(E)	Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1); scFv Fragment	FC, ELISA	Human scFv
FAMAB-0358WJ-S(P)	Human Anti-TNFRSF8 Recombinant Antibody (clone AK30); scFv Fragment	ELISA, WB	Human scFv

CAT	Product Name	Application	Type
AFC-TAB-153	Afuco™ Anti-TNFRSF8 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-153)	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody

CAT	Product Name	Application	Type
HPAB-1929-FY	Human Anti-TNFRSF8 Recombinant Antibody (clone 17G1)	ELISA, FC, ADCC	Human IgG
HPAB-1930-FY	Human Anti-TNFRSF8 Recombinant Antibody (clone 2H9)	ELISA, FC, ADCC	Human IgG
HPAB-1931-FY	Human Anti-TNFRSF8 Recombinant Antibody (clone 5F11)	ELISA, FC, ADCC, Inhib, FuncS	Human IgG
VS3-FY272	Recombinant Mouse Anti-TNFRSF8 Antibody (clone 1B1A4G2)	ELISA, WB, ICC, FC	Mouse IgG1
VS3-FY273	Recombinant Mouse Anti-TNFRSF8 Antibody (clone 2A5A4)	ELISA, ICC, FC	Mouse IgG1

CAT	Product Name	Application	Type
VS-0724-XY50	Mouse Anti-TNFRSF8 Agonistic Antibody (VS-0724-XY50)	WB, FC, Agonistic assays, CyTOF®	Mouse IgG2b

CAT	Product Name	Application	Type
VS-0125-FY77	Human Anti-TNFRSF8 (clone Iratumumab) scFv-Fc Chimera	ELISA, FC, IP, FuncS, IF, Neut	Human IgG1, scFv-Fc
VS-0325-FY13	Human Anti-TNFRSF8 scFv-Fc Chimera (VS-0325-FY13)	ELISA	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY223	CytoStream™ Armenian Hamster Anti-TNFRSF8 Recombinant Antibody (VS-0225-XY223)	FC	Armenian Hamster IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC248	Recombinant Anti-TNFRSF8 Vesicular Antibody, EV Displayed (VS-0425-YC248)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY7385	Anti-TNFRSF8 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC181	Recombinant Anti-TNFRSF8 (Ep2 x Ep7) Biparatopic Antibody, Tandem scFv (Clone T215 x Clone T408)	ELISA, FC, WB	Tandem scFv
VS-0525-YC183	Recombinant Anti-TNFRSF8 (AA 107-153 x AA 282-338) Biparatopic Antibody, Tandem scFv (Clone T105 x Clone T405)	ELISA, WB	Tandem scFv
VS-0525-YC234	Recombinant Anti-TNFRSF8 Biparatopic Antibody, Tandem scFv	ELISA, FC, ICC, IF, IP, Neut	Tandem scFv

Specific Inquiry

Size:

Conjugation:

Endotoxin:

Purity:

Formats:

Isotype Switching:

Fc Engineering:

Modalities:

Add to compare

Request
Custom Production

See Our Custom Production in Action

Figure 1 Anti-HBV Recombinant Antibody (TAB-147) in SDS-PAGE

Download the full case study

Popular Products

Figure 3 Anti-ANGPT2 Therapeutic Antibody (TAB-769) in ELISA

Anti-ANGPT2 Recombinant Antibody (CAT# TAB-769)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 5 Anti-Human ErbB2 Recombinant Antibody (Trastuzumab) (TAB-005) in SDS-PAGE

Anti-Human ErbB2 Recombinant Antibody (TAB-005) (CAT# TAB-005)
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC

Figure 2 Anti-SDC1 Antibody (TAB-197) in ELISA

Chimeric (Mouse/Human) Anti-SDC1 Recombinant Antibody (TAB-197) (CAT# TAB-197)
Application: Neut, ELISA, IF, IP, FuncS, FC, ICC

Figure 5 GPNMB Recombinant Antibody (TAB-751) in ELISA

Human Anti-GPNMB Recombinant Antibody (clone Glembatumumab) (CAT# TAB-751)
Application: WB, IF, IP, Neut, FuncS, ELISA, FC

Figure 4 Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) in ELISA

Anti-Human TRAIL-R2 Recombinant Antibody (TAB-196) (CAT# TAB-196)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 1 Anti-Human IL5 Recombinant Antibody (TAB-031) in SDS-PAGE

Anti-Human IL5 Recombinant Antibody (TAB-031) (CAT# TAB-031)
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC

Figure 3 Llama Anti-human IgG-CH1 VHH Single Domain Antibody (VHH-His-Cys) (NABG-112-UN) in DB

Llama Anti-human IgG-CH1 VHH Single Domain Antibody [Biotin] (CAT# NABG-112)
Application: ELISA, WB, BLI, SPR

Figure 1 Recombinant Human Anti-DENV E proteins Antibody (PABL-067) in SDS-PAGE

Recombinant Human Anti-DENV E proteins Antibody (5J7) (CAT# PABL-067)
Application: ELISA, Neut, FuncS

Figure 4 Human Anti-HIV-1 Env Recombinant Antibody (PABL-151) in ELISA

Human Anti-HIV-1 Env Recombinant Antibody (clone PGDM1400) (CAT# PABL-151)
Application: Neut, FuncS

Figure 3 Human Anti-HIV-1 gp41 Recombinant Antibody (clone 4E10) (PABL-192) in Dot Blot

Human Anti-HIV-1 gp41 Recombinant Antibody (clone 4E10) (CAT# PABL-192)
Application: WB, Neut, FuncS

Figure 2 Anti-PF4 Recombinant Antibody (PABL-299) in HPLC

Mouse Anti-PF4 Recombinant Antibody (clone KKO) (CAT# PABL-299)
Application: ELISA, FuncS

Figure 2 Anti-Kallikrein-2 Recombinant Antibody (TAB-0622CL) in HPLC

Mouse Anti-KLK2 Recombinant Antibody (TAB-0622CL) (CAT# TAB-0622CL)
Application: FuncS, IF

Figure 3 Anti-Human SIRPA Antibody (TAB-453CT) in ELISA

Human Anti-SIRPA Recombinant Antibody (TAB-453CT) (CAT# TAB-453CT)
Application: Cyt, IF, FC

Figure 1 Anti-Human TfR Recombinant Antibody (TAB-628CT) in SDS-PAGE

Anti-Human TfR Recombinant Antibody (3GH7 ) (CAT# TAB-628CT)
Application: WB

Figure 2 Anti-Human TfR Recombinant Antibody Fab Fragment (TAB-611CT-F(E)) in WB

Humanized Anti-TFRC Recombinant Antibody; Fab Fragment (TAB-611CT-F(E)) (CAT# TAB-611CT-F(E))
Application: ELISA

Figure 8 Anti-Influenza A Virus Hemagglutinin H3 HA Recombinant Antibody (MRO-280LC) in DB

Mouse Anti-Influenza A Virus Hemagglutinin H3 HA Recombinant Antibody (MRO-280LC) (CAT# MRO-280LC)
Application: WB, ELISA, IF

Figure 2 Human CRCP Recombinant Antibody (TAB-426CQ) in HPLC

Human Anti-CRCP Recombinant Antibody (TAB-426CQ) (CAT# TAB-426CQ)
Application: ELISA, IHC, FC, IP, IF, Inhib

Figure 5 Human Anti-FAP Recombinant Antibody (HPAB-0175-CN) in ELISA

Human Anti-FAP Recombinant Antibody (clone ESC14) (CAT# HPAB-0175-CN)
Application: ELISA, WB, FC, IHC, IP

Figure 2 Recombinant Human Anti-EBV gH/gL Antibody (AMMO1) (PABC-311) in SEC-HPLC

Recombinant Human Anti-EBV gH/gL Antibody (AMMO1) (CAT# PABC-311)
Application: ELISA, BLI, Neut

Figure 4 Human Anti-PEG Recombinant Antibody (FAMAB-1525CQ) in ELISA

Human Anti-PEG Recombinant Antibody (clone E11) (CAT# FAMAB-1525CQ)
Application: WB, ELISA, FC

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.