Human Anti-TNFRSF9 Recombinant Antibody (clone Hz4B4-1); scFv Fragment (CAT#: HPAB-0011-YJ-S(P))
This product is a recombinant humanized scFv that recognizes human 4-1BB. Mab Hz4B4-1 could interfere with 4-1BB/4-1BBL interaction that plays an important role in T cell activation and could eliminate 4-1BB expressing T cells via complement-dependent cytotoxicity and antibody-dependent cellular toxicity. Hz4B4-1 could also be used for the treatment of other T-cell mediated autoimmune diseases and graft rejections.
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoli & plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/71425/1522_F4_1_selected.jpg
Figure 2 RNA cell line category: Cell line enriched (HDLM-2)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000049249-TNFRSF9
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Humanized scFv
- Specificity
- Human TNFRSF9
- Species Reactivity
- Human
- Clone
- Hz4B4-1
- Applications
- ELISA, FC
- Related Disease
- Autoimmune Diseases, Transplant Rejection, Arthritis
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- TNF Receptor Superfamily Member 9; T-Cell Antigen 4-1BB Homolog; 4-1BB Ligand Receptor; CD137 Antigen; CDw137; CD137; ILA; Interleukin-Activated Receptor, Homolog Of Mouse Ly63; Tumor Necrosis Factor Receptor Superfamily, Member 9; Hz4B4-1; MAb Hz4B4-1
- Gene ID
- 3604
- UniProt ID
- Q07011
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-179 | Anti-Human 4-1BB Recombinant Antibody (TAB-179) | ELISA, FC, IP, FuncS, IF, Neut, ICC | IgG4 - kappa |
| TAB-457CQ | Anti-Human TNFRSF9 Recombinant Antibody (TAB-457CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, λ |
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For Research Use Only. Not For Clinical Use.
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