Anti-TNFSF13 (clone W24V79) Recombinant Antibody Coupled Liposome (VS-1024-FY81)
CAT#: VS-1024-FY81
Liposomes conjugated with anti-APRIL antibodies represent a promising approach for the treatment of gliomas, harnessing targeted delivery mechanisms to improve patient outcomes. By fusing antibodies with liposomes, these nanocarriers not only enhance the specificity of drug delivery to tumor cells but also facilitate a more sustained release of therapeutic agents directly at the tumor site. This innovative strategy could significantly bolster the effectiveness of existing treatments, paving the way for more successful interventions in the battle against aggressive brain tumors.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_B_8_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_A_7_3.jpg
Normal Tissue
Figure 3 Pancreas
Exocrine glandular cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_A_2_3.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4863/13948_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (EFO-21, RPMI-8226, RPTEC TERT1, U-937)
Cell lines ordered by descending RNA expression order.
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (EFO-21, RPMI-8226, RPTEC TERT1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000161955-TNFSF13
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More Infomation
Specifications
- Potential Clinical Applications
- Glioma
Product Composition
- Clone
- W24V79
- Antibody Type
- IgG
- Antibody Host
- Human
- Antibody Reactivity
- Human
- Antibody Description
- The recombinant human antibody exhibits a high degree of specificity and binding affinity towards human APRIL (A Proliferation-Inducing Ligand). This unique interaction highlights the antibody's potential applications in therapeutic and diagnostic settings related to disorders associated with APRIL, which plays a crucial role in immune regulation and cell proliferation.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- TNFSF13
- Introduction
- The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13.
- Alternative Names
- TNF Superfamily Member 13; Tumor Necrosis Factor (Ligand) Superfamily, Member 13; TNF- And APOL-Related Leukocyte Expressed Ligand 2; A Proliferation-Inducing Ligand; TALL-2; TRDL-1; APRIL; TALL2; ZTNF2; Tumor Necrosis Factor Ligand Superfamily Member 13
- Full Name
- TNF Superfamily Member 13
- Gene ID
- 8741
- UniProt ID
- O75888
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- The precursor is cleaved by furin. (O75888-TNF13_HUMAN)
Glycosylation at Asn124 (NX_O75888 [NX_O75888-1])
Modification sites at PhosphoSitePlus (O75888)
Glycosylation from GlyConnect TNF13_HUMAN (2946)
Glycosylation from GlyGen (O75888) 1 site, 15 N-linked glycans (1 site)
- Protein Refseq
- NP_001185551.1; NP_001185552.1; NP_001185553.1; NP_003799.1; NP_742084.1
- Function
- Plays a role in the regulation of tumor cell growth.
May be involved in monocyte/macrophage-mediated immunological processes.
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Datasheet
MSDS
COA
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| HPAB-0041CQ-F(E) | Mouse Anti-TNFSF13 Recombinant Antibody Fab Fragment (HPAB-0041CQ-F(E)) | ELISA, Neut | Mouse Fab |
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| HPAB-0042CQ-F(E) | Mouse Anti-TNFSF13 Recombinant Antibody Fab Fragment (HPAB-0042CQ-F(E)) | ELISA, Neut | Mouse Fab |
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