Mouse Anti-TNFSF14 Recombinant Antibody (VS3-FY2770) (CAT#: VS3-FY2770)
This anti-TNFSF14 antibody is a mouse recombinant monoclonal antibody that is created to attach to CD258 protein, a calculated weight of 26.4 kDa. It shows capability of cross-reacting with human and mouse. The monoclonal antibody can be used in the area of Rheumatoid Arthritis and Inflammatory Bowel Disease. This monoclonal antibody can be used in Western Blot, Immunohistochemistry, Flow cytometry, ELISA.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line THP-1
(Immunofluorescent staining of human cell line THP-1 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/2061_E6_3_selected.jpg
(Immunofluorescent staining of human cell line THP-1 shows localization to vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/2061_E6_3_selected.jpg
Figure 2 IHC staining of human urinary bladder
(Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/ihc_selected.jpg
(Immunohistochemical staining of human urinary bladder shows strong cytoplasmic positivity in umbrella cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/ihc_selected.jpg
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_3.jpg
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_3.jpg
Figure 4 Liver
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_4.jpg
(Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_9_4.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_8_5.jpg
Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_4_6.jpg
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12700/57480_A_4_6.jpg
Figure 7 RNA cell line category: Cell line enhanced (HDLM-2, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125735-TNFSF14
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000125735-TNFSF14
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- TNF superfamily member 14 of human and mouse origins
- Species Reactivity
- Human, Mouse
- Applications
- WB, IHC, FC, ELISA
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 26.4 kDa.
- Related Disease
- Rheumatoid Arthritis and Inflammatory Bowel Disease
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Immunohistochemistry: 1/50-1/200
Flow cytometry: 1/50-1/200
ELISA: 1/1000-1/10000
Target
- Alternative Names
- TNF Superfamily Member 14; Tumor Necrosis Factor (Ligand) Superfamily, Member 14; Herpesvirus Entry Mediator Ligand; HVEML; LIGHT; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor Superfamily Member 14
- Gene ID
- 8740
- Sequence Similarities
- Belongs to the tumor necrosis factor family.
- Cellular Localization
- Cytoplasm
- Post Translation Modifications
- N-glycosylated.
The soluble form of isoform 1 derives from the membrane form by proteolytic processing.
Glycosylation at Asn102
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- NP_001363816.1; NP_003798.2; NP_742011.2
- Function
- Acts as a ligand for TNFRSF14/HVEM (PubMed:9462508, 10754304).
Upon binding to TNFRSF14/HVEM, delivers costimulatory signals to T cells, leading to T cell proliferation and IFNG production.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-159CQ | Anti-Human TNFSF14 Recombinant Antibody (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-S(P) | Anti-Human TNFSF14 Recombinant Antibody scFv Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
| TAB-159CQ-F(E) | Anti-Human TNFSF14 Recombinant Antibody Fab Fragment (TR01G03) | ELISA, FC, WB | Human antibody |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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