Afuco™ Anti-TNFSF4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-223)

Name: Afuco™ Anti-TNFSF4 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-223)
SKU: AFC-TAB-223
Rating: 5 (1 reviews)

CAT#: AFC-TAB-223

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to CD252. It is a human monoclonal antibody designed for the treatment of asthma.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line BJ

Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & vesicles.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/1331_F5_1_selected.jpg

Normal Tissue Figure 2 IHC staining of human tonsil

Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in non-germinal center cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_4_8_selected.jpg

Normal Tissue Figure 3 Duodenum

Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_8_2.jpg

Normal Tissue Figure 4 Colon

Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_9_3.jpg

Normal Tissue Figure 5 Testis

Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_6_6.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/59579/134109_A_8_8.jpg

RNA Expression Figure 7 RNA cell line category: Cell line enhanced (fHDF/TERT166, HHSteC, HUVEC TERT2, LHCN-M2)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000117586-TNFSF4

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Specifications

Immunogen
The details of the immunogen for this antibody are not available.

Host Species
Human

Derivation
Human

Type
ADCC enhanced antibody

Antibody Isotype
IgG1, κ

Species Reactivity
Human

Applications
ELISA, FC, IP, FuncS, IF, Neut

Conjugate
Unconjugated

Generic Name
Oxelumab

Related Disease
Asthma

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
TNFSF4; tumor necrosis factor (ligand) superfamily, member 4; tax transcriptionally activated glycoprotein 1, 34kD, TXGP1; tumor necrosis factor ligand superfamily member 4; CD252; gp34; OX 40L; OX40L

Gene ID
7292

UniProt ID
P23510

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Downloadable Resources

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-223.pdf

MSDS

MSDS - AFC-TAB-223.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

See other products for "Oxelumab"

DrugMonitor™ Anti-Oxelumab Antibody (VS-1224-YC868)
Oxelumab (R 4930) is a human monoclonal antibody directed against OX40L and is currently under investigation in clinical trials for adults with mild allergic asthma. The DrugMonitor™ Anti-Oxelumab Antibody (VS-1224-YC868) is an anti-drug antibody (ADA) against Oxelumab. This drug-based antibody is raised in mice immunized with the Oxelumab. The anti-Oxelumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Oxelumab in samples.

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