AbPlus™ Anti-TNK1 Magnetic Beads (VS-0424-XY259)
CAT#: VS-0424-XY259
The AbPlus Anti-TNK1 Magnetic Beads (VS-0424-XY259) is an innovative affinity resin which is bound with anti-TNK1 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of TNK1 protein under native and denaturing conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/56452/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells and cells in molecular layer.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12065/52231_B_7_8_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12065/52231_B_7_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12065/52231_A_9_3.jpg
Normal Tissue
Figure 5 Testis
Leydig cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12065/52231_A_4_6.jpg
Normal Tissue
Figure 6 Ovary
Follicle cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/12065/52231_A_4_7.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000174292-TNK1
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-TNK1 specific antibody
- Target
- TNK1
- Target Species
- Human
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Alternative Names
- TNK1; Tyrosine kinase non receptor 1; non-receptor tyrosine-protein kinase TNK1; CD38 negative kinase 1
- Gene ID
- 8711
- UniProt ID
- Q13470
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "TNK1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2434-sdAb | Recombinant Anti-Human TNK1 VHH Single Domain Antibody | IHC, IP, FC, Neut, FUNC | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-151CQ | Mouse Anti-TNK1 Recombinant Antibody (TAB-151CQ) | ELISA, FC, WB, IP, IHC | Mouse IgG |
| TAB-152CQ | Mouse Anti-TNK1 Recombinant Antibody (TAB-152CQ) | ELISA, FC, WB, IP, IHC | Mouse IgG |
| TAB-151CQ-S(P) | Mouse Anti-TNK1 Recombinant Antibody; scFv Fragment (TAB-151CQ-S(P)) | ELISA, FC, WB, IP, IHC | Mouse scFv |
| TAB-152CQ-S(P) | Mouse Anti-TNK1 Recombinant Antibody; scFv Fragment (TAB-152CQ-S(P)) | ELISA, FC, WB, IP, IHC | Mouse scFv |
| TAB-151CQ-F(E) | Mouse Anti-TNK1 Recombinant Antibody; Fab Fragment (TAB-151CQ-F(E)) | ELISA, FC, WB, IP, IHC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2098CT | Recombinant Mouse anti-Human TNK1 Monoclonal antibody (4G22I7) | ELISA, WB | |
| ZG-149R | Mouse Anti-TNK1 Recombinant Antibody (ZG-149R) | WB, ELISA | Mouse IgG |
| VS7-0425-WR1029 | Mouse Anti-TNK1 Monoclonal Antibody (clone 1B5G3) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2320 | Anti-TNK1 Immunohistochemistry Kit | IHC |
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