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    Chicken Anti-TOP1 Recombinant Antibody (clone 5C2); Fab Fragment (CAT#: FAMAB-0004JF-F(E))

    Recombinant chicken monoclonal antibody specially binds to human Topo1. This anti-Topo1 antibody 5C2 can be potentially wildly used in the treatment of systemic sclerosis.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-2 OS
    Figure 1 IF staining of human cell line U-2 OS
    (Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & nucleoli fibrillar center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/154_H7_2_selected.jpg
    Figure 2 IHC staining of human appendix
    Figure 2 IHC staining of human appendix
    (Immunohistochemical staining of human appendix shows general nuclear positivity.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_A_3_2_selected.jpg
    Figure 3 IHC staining of human cerebral cortex
    Figure 3 IHC staining of human cerebral cortex
    (Immunohistochemical staining of human cerebral cortex shows strong nuclear positivity in glial cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9058/ihc_selected.jpg
    Figure 4 IF staining of human cell line A-431
    Figure 4 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to nucleoplasm & nucleoli fibrillar center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/198_H7_1_red_green.jpg
    Figure 5 IF staining of human cell line U-251 MG
    Figure 5 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nucleoli fibrillar center.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/152_H7_1_red_green.jpg
    Normal Tissue
    Figure 6 Cerebral cortex
    Figure 6 Cerebral cortex
    (Glial cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Nuclear
    Neuronal cells
    Staining:

    High

    Intensity: Strong
    Quantity: 75%-25%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_B_9_5.jpg
    Figure 7 Colon
    Figure 7 Colon
    (Glandular cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_A_7_3.jpg
    Figure 8 Kidney
    Figure 8 Kidney
    (Cells in tubules
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_A_8_5.jpg
    Figure 9 Urinary bladder
    Figure 9 Urinary bladder
    (Urothelial cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_A_5_5.jpg
    Figure 10 Testis
    Figure 10 Testis
    (Leydig cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_A_4_6.jpg
    Figure 11 Lymph node
    Figure 11 Lymph node
    (Non-germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity: 75%-25%
    Location: Nuclear)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/19039/43952_A_9_8.jpg
    RNA Expression
    Figure 12 RNA cell line category: Low cell line specificity
    Figure 12 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * https://v21.proteinatlas.org/ENSG00000198900-TOP1
    Figure 12 RNA cell line category: Low cell line specificity
    Figure 12 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000198900-TOP1

    Specifications

    • Immunogen
    • Antigen mixture 1 (annexin XI, centromere protein B, DNA topoisomerase I, histidyl tRNA synthetase, Ro60, Rpp38 and U1A) and mixture 2 (a-fodrin, human Pop1 protein, heat shock protein B3, Ro52, Rpp30, Rrp4 and Rrp42)
    • Host Species
    • Chicken
    • Derivation
    • Chicken phage display scFv library
    • Type
    • Chicken Fab
    • Specificity
    • Human Topo1
    • Species Reactivity
    • Human
    • Clone
    • 5C2
    • Applications
    • IB, WB, ELISA, FuncS
    • Related Disease
    • Systemic sclerosis

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Buffer
    • PBS
    • Preservative
    • No preservatives
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

    Target

    • Alternative Names
    • TOPI

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone 5C2"

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    Select a product category from the dropdown menu below to view related products.
    Please select product type
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    CAT Product Name Application Type
    MOR-3638 Rabbit Anti-TOP1 Recombinant Antibody (clone DS3638AB) FC, ICC, IF, IHC-P, WB Rabbit IgG

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