Anti-TOP2A (clone W24V135) Recombinant Antibody Coupled Liposome (VS-1024-FY136) (CAT#: VS-1024-FY136)

• Potential Clinical Applications
• Glioma

• Clone
• W24V135

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that exhibits specific binding affinity for human topoisomerase II alpha (TOP2A). Through its unique structure and design, this antibody can effectively recognize and target TOP2A, a critical enzyme involved in DNA replication and repair processes. The targeted interaction between the antibody and TOP2A holds significant potential for applications in cancer research and therapeutics, as TOP2A is often overexpressed in various tumor types.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• TOP2A

• Introduction
• This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

• Alternative Names
• DNA Topoisomerase II Alpha; Topoisomerase (DNA) II Alpha 170kDa; DNA Topoisomerase II, Alpha Isozyme; EC 5.99.1.3; TOP2; DNA Topoisomerase (ATP-Hydrolyzing)

• Full Name
• DNA Topoisomerase II Alpha

• Gene ID
• 7153

• UniProt ID
• P11388

• Sequence Similarities
• Belongs to the type II topoisomerase family.

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Phosphorylation has no effect on catalytic activity. However, phosphorylation at Ser-1106 by CSNK1D/CK1 promotes DNA cleavable complex formation.

• Protein Refseq
• NP_001058.2

• Function
• Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612).
  May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation (By similarity).

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