Rabbit Anti-TP73 Recombinant Antibody (clone R09-1J5) (CAT#: VS3-XY3528)

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Human, Mouse and Rat TP73

• Species Reactivity
• Human, Mouse, Rat

• Clone
• R09-1J5

• Applications
• WB, IHC-P, ICC, IF

• Related Disease
• Ciliary Dyskinesia, Primary, 47; Small Cell Cancer of The Lung

• Clonality
• Monoclonal

• Aggregation
• < 5%

• Format
• Liquid

• Buffer
• PBS (pH 7.4), 150 mM NaCl and 50% glycerol

• Preservative
• 0.02% sodium azide

• Storage
• Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• WB: 1/500-1/1000
  IHC: 1/50-1/100
  IF: 1/50-1/200

• Alternative Names
• P73; CILD47

• Gene ID
• 7161

• UniProt ID
• O15350

• Long Name
• Tumor protein p73

• Cellular Localization
• Cytoplasm, Nucleus

• Post Translation Modifications
• Higher levels of phosphorylation seen in the brain from patients with Huntington disease. (O15350-P73_HUMAN)
  Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome. (O15350-P73_HUMAN)
  Modification sites at PhosphoSitePlus (O15350)
  Modification sites at neXtProt (NX_O15350)

• Protein Refseq
• XP_047285480.1

• Function
• Participates in the apoptotic response to DNA damage.
  Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms.
  May be a tumor suppressor protein.
  Is an activator of FOXJ1 expression (By similarity).
  It is an essential factor for the positive regulation of lung ciliated cell differentiation.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Recommended Dilution Buffer

• MRO-0253YJ
• Reconstitution Buffer PBS

Secondary Antibody

• 2RD-A1473-YJ
• Goat Anti-Rabbit IgG-F(ab')2 Secondary antibody

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