Rabbit Anti-TP73 Recombinant Antibody (clone R09-1J5) (CAT#: VS3-XY3528)
It is a recombinant rabbit antibody specific for TP73 (Tumor protein p73), which is an essential factor for the positive regulation of lung ciliated cell differentiation. The antibody specifically reacts with human, mouse and rat TP73. This product has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western blot, Immunohistochemistry-Paraffin and Immunofluorescence is 1/500-1/1000, 1/50-1/100 and 1/50-1/200, respectively.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/27314/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/27314/if_selected.jpg
Figure 2 IF staining of human cell line HEK 293
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44516/if_selected.jpg
(Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & the Golgi apparatus.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/44516/if_selected.jpg
Figure 3 Skin 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1_val_selected.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_8_5.jpg
Figure 5 Skin
(Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1.jpg
(Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1.jpg
Figure 6 RNA cell line category: Cell line enhanced (MOLT-4, RH-30, SCLC-21H, U-698)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078900-TP73
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078900-TP73
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TP73
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-1J5
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Ciliary Dyskinesia, Primary, 47; Small Cell Cancer of The Lung
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- P73; CILD47
- Gene ID
- 7161
- UniProt ID
- O15350
- Long Name
- Tumor protein p73
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Higher levels of phosphorylation seen in the brain from patients with Huntington disease. (O15350-P73_HUMAN)
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome. (O15350-P73_HUMAN)
Modification sites at PhosphoSitePlus (O15350)
Modification sites at neXtProt (NX_O15350)
- Protein Refseq
- XP_047285480.1
- Function
- Participates in the apoptotic response to DNA damage.
Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms.
May be a tumor suppressor protein.
Is an activator of FOXJ1 expression (By similarity).
It is an essential factor for the positive regulation of lung ciliated cell differentiation.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TP73"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1619z | Mouse Anti-TP73 Recombinant Antibody (clone 25G9) | WB, ICC, IHC, IP | Mouse IgG |
| MRO-1157-CN | Rabbit Anti-TP73 Recombinant Antibody (clone CBACN-420) | WB, IF, IHC | Rabbit IgG |
| VS3-CJ137 | Rabbit Anti-TP73 Recombinant Antibody (VS3-CJ137) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-FY1476 | Recombinant Rabbit Anti-TP73 Antibody (clone R07-1J7) | WB, IP, ChIP | Rabbit IgG |
| VS13-YC1179 | Rabbit Anti-TP73 Recombinant Antibody (VS13-YC1179) | IHC-P | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
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