Rabbit Anti-TP73 Recombinant Antibody (clone R09-1J5)
CAT#: VS3-XY3528
It is a recombinant rabbit antibody specific for TP73 (Tumor protein p73), which is an essential factor for the positive regulation of lung ciliated cell differentiation. The antibody specifically reacts with human, mouse and rat TP73. This product has been reported for use in Western Blot, Immunohistochemistry-Paraffin, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western blot, Immunohistochemistry-Paraffin and Immunofluorescence is 1/500-1/1000, 1/50-1/100 and 1/50-1/200, respectively.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm, cell junctions & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/27314/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoplasm & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/44516/if_selected.jpg
Normal Tissue
Figure 3 Skin 1
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1_val_selected.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_8_5.jpg
Normal Tissue
Figure 5 Skin
Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2514/142954_B_7_1.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (MOLT-4, RH-30, SCLC-21H, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000078900-TP73
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TP73
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-1J5
- Applications
- WB, IHC-P, ICC, IF
- Related Disease
- Ciliary Dyskinesia, Primary, 47; Small Cell Cancer of The Lung
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
Target
- Alternative Names
- P73; CILD47
- Gene ID
- 7161
- UniProt ID
- O15350
- Long Name
- Tumor protein p73
- Cellular Localization
- Cytoplasm, Nucleus
- Post Translation Modifications
- Higher levels of phosphorylation seen in the brain from patients with Huntington disease. (O15350-P73_HUMAN)
Polyubiquitinated by RCHY1/PIRH2; leading to its degradation by the proteasome. (O15350-P73_HUMAN)
Modification sites at PhosphoSitePlus (O15350)
Modification sites at neXtProt (NX_O15350)
- Protein Refseq
- XP_047285480.1
- Function
- Participates in the apoptotic response to DNA damage.
Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms.
May be a tumor suppressor protein.
Is an activator of FOXJ1 expression (By similarity).
It is an essential factor for the positive regulation of lung ciliated cell differentiation.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "TP73"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1619z | Mouse Anti-TP73 Recombinant Antibody (clone 25G9) | WB, ICC, IHC, IP | Mouse IgG |
| MOB-1519CT | Recombinant Mouse anti-Human TP73 Monoclonal antibody (FS-26) | GSA, ICC, IF, IHC-P, IP, WB | |
| MRO-1157-CN | Rabbit Anti-TP73 Recombinant Antibody (clone CBACN-420) | WB, IF, IHC | Rabbit IgG |
| VS3-CJ137 | Rabbit Anti-TP73 Recombinant Antibody (VS3-CJ137) | WB, ICC, IF, IHC | Rabbit IgG |
| VS3-FY1476 | Recombinant Rabbit Anti-TP73 Antibody (clone R07-1J7) | WB, IP, ChIP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3648 | Rabbit Anti-TP73 Recombinant Antibody (clone DS3648AB) | IHC-Fr, WB, IP, ICC, IF, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7450 | Anti-TP73 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7451 | Anti-Mouse TP73 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7452 | Anti-Rat TP73 Immunohistochemistry Kit | IHC |
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