Human Anti-TPM4 Recombinant Antibody (clone D09) (CAT#: VS-0723-CJ49)
This is a human monoclonal antibody against human tropomyosin alpha-4 chain (TPM4) and can be used to detect TPM4 present in saliva of patients with OSCC. This antibody has been tested for use in enzyme-linked immunosorbent assay and immunohistochemistry assays.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4685/if_selected.jpg
(Immunofluorescent staining of human cell line A-431 shows localization to actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4685/if_selected.jpg
Figure 2 IHC staining of human placenta
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4685/ihc_selected.jpg
(Immunohistochemical staining of human placenta shows strong cytoplasmic positivity in trophoblastic cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4685/ihc_selected.jpg
Figure 3 Colon
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47089/124544_A_7_3.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47089/124544_A_7_3.jpg
Figure 4 Smooth muscle
(Smooth muscle cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47089/124544_B_5_7.jpg
(Smooth muscle cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/47089/124544_B_5_7.jpg
Figure 5 RNA cell line category: Cell line enhanced (U-2197)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167460-TPM4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000167460-TPM4
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human tropomyosin alpha-4 chain (TPM4)
- Species Reactivity
- Human
- Clone
- D09
- Applications
- ELISA, IHC
- Conjugate
- Unconjugated
- Related Disease
- Oral cancer
Product Property
- Purification
- Protein A purified
- Purity
- >95%
- Buffer
- PBS
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody clone D09 was able to distinguish saliva of OSCC patients from healthy subjects by ELISA with sensitivity and specificity of 96.67%. This antibody presented a positive immunostaining for invasive malignant epithelial cells in the connective tissue, keratin pearls in the OSCC, and ducts of salivary glands. Immunohistochemical analysis of this antibody was performed in OSCC tissues. [PMC6895045]
Target
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2094CT | Recombinant Mouse anti-Human TPM4 Monoclonal antibody (EML2367) | ICC/IF, IHC-P, WB |
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For Research Use Only. Not For Clinical Use.
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