CytoStream™ Rabbit Anti-TPPP Recombinant Antibody (VS13-YC1182)
CAT#: VS13-YC1182
The CytoStream™ Rabbit Anti-TPPP Recombinant Antibody is specific for human, mouse and rat TPPP. TPPP encodes a tubulin polymerization promoter, involved in pathways like glial differentiation, with links to conditions like Lewy Body Dementia. The anti-TPPP antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to cytosol & mitochondria.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36576/1719_G6_18_cr5804b9cccd554_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36575/141824_B_9_5.jpg
Normal Tissue
Figure 3 Colon
Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36575/141824_A_9_3.jpg
Normal Tissue
Figure 4 Pancreas
Pancreatic endocrine cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36575/141824_A_3_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36575/141824_A_9_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: nuclear Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36575/141824_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A549, AN3-CA, SCLC-21H)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000171368-TPPP
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Specifications
- Immunogen
- Recombinant human TPPP.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TPPP
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, IHC-P, ICC, IF, FC
- Conjugate
- NONE
- Related Disease
- Lymphoid Interstitial Pneumonia and Dementia, Lewy Body
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.4) containing 150 mM NaCl and 50% Glycerol.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry (IHC): 1/50-1/100
Immunofluorescence (IF): 1/50-1/200
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- Tubulin Polymerization Promoting Protein; Brain Specific Protein P25 Alpha; 25 KDa Brain-Specific Protein; P25-Alpha; TPPP/P25; TPPP1;
- Gene ID
- 11076
- UniProt ID
- O94811
- Long Name
- Tubulin Polymerization Promoting Protein
- Sequence Similarities
- Belongs to the TPPP family.
- Cellular Localization
- Cytoplasm; Cytoskeleton; Golgi apparatus; Nucleus
- Protein Refseq
- XP_016864482.1; XP_024310114.1; XP_047272630.1; XP_054207487.1; XP_054207488.1
- Function
- Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath.
Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TPPP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3660 | Rabbit Anti-TPPP Recombinant Antibody (clone DS3660AB) | WB, IP, IHC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-WK375 | Rabbit Anti-TPPP Recombinant Antibody (clone JE47-35) | WB, IHC, FC | Rabbit IgG |
| VS3-FY1920 | Rabbit Anti-TPPP Recombinant Antibody (clone R06-8I4) | WB, IHC-Fr, IHC-P, IF | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2339 | Anti-TPPP Immunohistochemistry Kit | IHC | |
| VS-0525-XY7472 | Anti-Mouse TPPP Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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