Human Anti-TREM2 Recombinant Antibody (VS-0624-FY66)
CAT#: VS-0624-FY66
This is a recombinant monoclonal antibody that was designed to specifically target human TREM2, with demonstrated cross-reactivity to mouse TREM2. Its binding capability extends to both human and mouse cell lines, making it a versatile tool for laboratory applications. The recommended use for this antibody is in flow cytometry assays.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human gallbladder
Immunohistochemical staining of human gallbladder shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_4_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Glial cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_B_8_5.jpg
Normal Tissue
Figure 3 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/10917/26581_A_6_6.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (hTCEpi, THP-1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000095970-TREM2
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| Sub Cat | Clone | Affinity Constant | Applications | Epitope | Size | Conjugation | Endotoxin | Purity | Fc Engineering | |
| VS-0624-FY38 | Ab1 | KD = 7.05 nM (human); KD= 4.86 nM (mouse) | FC | AA 139-146: GDLWFPGE | ||||||
| VS-0624-FY39 | Ab65 | KD = 0.546 nM (human); KD= 1.56 nM (mouse) | Block, FC | AA 140-153: DLWFPGESESFEDA |
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human and mouse TREM2
- Species Reactivity
- Human, Mouse
- Clone
- Ab1
- Applications
- Flow Cytometry
- Related Disease
- Alzheimer's disease
Product Property
- Clonality
- Monoclonal Antibody
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Triggering Receptor Expressed On Myeloid Cells 2; Triggering Receptor Expressed On Myeloid Cells 2a; Triggering Receptor Expressed On Monocytes 2; TREM-2; Trem2a; Trem2b; Trem2c
- Gene ID
- 54209
- UniProt ID
- Q9NZC2
- Long Name
- Triggering Receptor Expressed On Myeloid Cells 2
- Cellular Localization
- Cell membrane; Secreted
- Post Translation Modifications
- Undergoes ectodomain shedding through proteolytic cleavage by ADAM10 and ADAM17 to produce a transmembrane segment, the TREM2 C-terminal fragment (TREM2-CTF), which is subsequently cleaved by gamma-secretase.
- Protein Refseq
- NP_001258750.1; NP_061838.1
- Function
- Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849).
Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia (PubMed:27477018, PubMed:29518356).
Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro-inflammatory cytokines, such as IL6R and CCL3, and the anti-inflammatory cytokine ARG1 (By similarity).
Acts as a receptor for lipoprotein particles such as LDL, VLDL, and HDL and for apolipoproteins such as APOA1, APOA2, APOB, APOE, APOE2, APOE3, APOE4, and CLU and enhances their uptake in microglia (PubMed:27477018).
Binds phospholipids (preferably anionic lipids) such as phosphatidylserine, phosphatidylethanolamine, phosphatidylglycerol and sphingomyelin (PubMed:29794134).
Regulates microglial proliferation by acting as an upstream regulator of the Wnt/beta-catenin signaling cascade (By similarity).
Required for microglial phagocytosis of apoptotic neurons (PubMed:24990881).
Also required for microglial activation and phagocytosis of myelin debris after neuronal injury and of neuronal synapses during synapse elimination in the developing brain (By similarity).
Regulates microglial chemotaxis and process outgrowth, and also the microglial response to oxidative stress and lipopolysaccharide (By similarity).
It suppresses PI3K and NF-kappa-B signaling in response to lipopolysaccharide; thus promoting phagocytosis, suppressing pro-inflammatory cytokine and nitric oxide production, inhibiting apoptosis and increasing expression of IL10 and TGFB (By similarity).
During oxidative stress, it promotes anti-apoptotic NF-kappa-B signaling and ERK signaling (By similarity).
Plays a role in microglial MTOR activation and metabolism (By similarity).
Regulates age-related changes in microglial numbers (PubMed:29752066).
Triggers activation of the immune responses in macrophages and dendritic cells (PubMed:10799849).
Mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity).
In dendritic cells, it mediates up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (PubMed:11602640).
Involved in the positive regulation of osteoclast differentiation (PubMed:12925681).
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "TREM2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-168CQ | Human Anti-TREM2 Recombinant Antibody (TAB-168CQ) | ELISA, FC, WB, FuncS | Human IgG |
| TAB-169CQ | Human Anti-TREM2 Recombinant Antibody (TAB-169CQ) | ELISA, FC, WB, FuncS | Human IgG |
| TAB-168CQ-S(P) | Human Anti-TREM2 Recombinant Antibody; scFv Fragment (TAB-168CQ-S(P)) | ELISA, FC, WB, FuncS | Human scFv |
| TAB-168CQ-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-168CQ-F(E)) | ELISA, FC, WB, FuncS | Human Fab |
| TAB-169CQ-F(E) | Human Anti-TREM2 Recombinant Antibody; Fab Fragment (TAB-169CQ-F(E)) | ELISA, FC, WB, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152-CN | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002) | ELISA, FC | Human IgG1, κ |
| HPAB-0153-CN | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005) | ELISA, FC | Human IgG1, κ |
| HPAB-0154-CN | Mouse Anti-TREM2 Recombinant Antibody (HPAB-0154-CN) | WB, ELISA, FC, IHC, IF, IP | Mouse IgG1 |
| HPAB-0155-CN | Mouse Anti-TREM2 Recombinant Antibody (HPAB-0155-CN) | WB, ELISA, FC, IHC, IF, IP | Mouse IgG1 |
| HPAB-0156-CN | Mouse Anti-TREM2 Recombinant Antibody (HPAB-0156-CN) | WB, ELISA, FC, IHC, IF, IP | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152-CN-S(P) | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0153-CN-S(P) | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005); scFv Fragment | ELISA, FC | Human scFv |
| HPAB-0154-CN-S(P) | Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0154-CN-S(P)) | WB, ELISA, FC, IHC, IF, IP | Mouse scFv |
| HPAB-0155-CN-S(P) | Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0155-CN-S(P)) | WB, ELISA, FC, IHC, IF, IP | Mouse scFv |
| HPAB-0156-CN-S(P) | Mouse Anti-TREM2 Recombinant Antibody; scFv Fragment (HPAB-0156-CN-S(P)) | WB, ELISA, FC, IHC, IF, IP | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0152-CN-F(E) | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.002); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0153-CN-F(E) | Human Anti-TREM2 Recombinant Antibody (clone Pil.02.005); Fab Fragment | ELISA, FC | Human Fab |
| HPAB-0154-CN-F(E) | Mouse Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0154-CN-F(E)) | WB, ELISA, FC, IHC, IF, IP | Mouse Fab |
| HPAB-0155-CN-F(E) | Mouse Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0155-CN-F(E)) | WB, ELISA, FC, IHC, IF, IP | Mouse Fab |
| HPAB-0156-CN-F(E) | Mouse Anti-TREM2 Recombinant Antibody; Fab Fragment (HPAB-0156-CN-F(E)) | WB, ELISA, FC, IHC, IF, IP | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-XY58 | Mouse Anti-TREM2 Agonistic Antibody (clone al002c) | Agonistic assays, DB, ICC, IP, SPR, IF | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY262 | AbPlus™ Anti-TREM2 Magnetic Beads (VS-0424-XY262) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2348 | Anti-TREM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7507 | Anti-Rat TREM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7508 | Anti-Mouse TREM2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7506 | Anti-Human TREM2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC228 | Recombinant Anti-TREM2 Vesicular Antibody, EV Displayed (VS-0425-YC228) | ELISA, FC, Cell-uptake |
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