Mouse Anti-TSC1 Recombinant Antibody (VS3-FY2908)
CAT#: VS3-FY2908
The anti-TSC1 antibody is a mouse recombinant monoclonal antibody that is designed to selectively bind to mouse TSC1 protein, a calculated molecular weight of the protein is about 129.8 kDa. The antibody can be utilized for detection of TSC1 by Western Blot (1/500-1/1000).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RH-30
Immunofluorescent staining of human cell line RH-30 shows localization to cytosol & lipid droplets.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/74132/1666_F4_31_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/if_selected.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_9_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_B_7_5.jpg
Normal Tissue
Figure 5 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_8_3.jpg
Normal Tissue
Figure 6 Liver
Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165699-TSC1
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Mouse TSC1
- Species Reactivity
- Mouse
- Applications
- Western Blot
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 129.8 kDa.
- Related Disease
- Tuberous Sclerosis 1 and Lymphangioleiomyomatosis
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Target
- Alternative Names
- TSC Complex Subunit 1; Tuberous Sclerosis 1 Protein; Hamartin; TSC; Tuberous Sclerosis 1; Tumor Suppressor; KIAA0243; LAM
- Gene ID
- 7248
- UniProt ID
- Q92574
- Cellular Localization
- Lysosome membrane
Peripheral membrane protein
Cytoplasm, cytosol
- Post Translation Modifications
- Phosphorylation at Ser-505 does not affect interaction with TSC2. (Q92574-TSC1_HUMAN)
Modification sites at PhosphoSitePlus (Q92574)
Modification sites at neXtProt (NX_Q92574)
Glycosylation from GlyGen (Q92574) 2 sites, 1 O-linked glycan (2 sites)
- Protein Refseq
- XP_054219693.1; NP_000359.1; NP_001155898.1; NP_001155899.1
- Function
- Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.
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Related Signaling Pathways
Insulin Signaling Pathway
mTOR Signaling Pathway
PI3K-Akt Signaling Pathway
Related Diseases
Insulin Resistance
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TSC1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3081z | Mouse Anti-TSC1 Recombinant Antibody (clone 36H8) | WB, FC, IHC | Mouse IgG2b |
| VS3-XY1551 | Mouse Anti-TSC1 Recombinant Antibody (clone 357CT4.4.2) | WB | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3700 | Rabbit Anti-TSC1 Recombinant Antibody (clone DS3700AB) | IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC1185 | CytoStream™ Mouse Anti-TSC1 Recombinant Antibody (VS13-YC1185) | WB, ICC, IF, IHC-P, FC | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2376 | Anti-TSC1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7563 | Anti-Mouse TSC1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7562 | Anti-Human TSC1 Immunohistochemistry Kit | IHC |
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