Mouse Anti-TSC1 Recombinant Antibody (VS3-FY2908) (CAT#: VS3-FY2908)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Mouse TSC1

• Species Reactivity
• Mouse

• Applications
• Western Blot

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 129.8 kDa.

• Related Disease
• Tuberous Sclerosis 1 and Lymphangioleiomyomatosis

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000

• Alternative Names
• TSC Complex Subunit 1; Tuberous Sclerosis 1 Protein; Hamartin; TSC; Tuberous Sclerosis 1; Tumor Suppressor; KIAA0243; LAM

• Gene ID
• 7248

• UniProt ID
• Q92574

• Cellular Localization
• Lysosome membrane
  Peripheral membrane protein
  Cytoplasm, cytosol

• Post Translation Modifications
• Phosphorylation at Ser-505 does not affect interaction with TSC2. (Q92574-TSC1_HUMAN)
  Modification sites at PhosphoSitePlus (Q92574)
  Modification sites at neXtProt (NX_Q92574)
  Glycosylation from GlyGen (Q92574) 2 sites, 1 O-linked glycan (2 sites)

• Protein Refseq
• XP_054219693.1; NP_000359.1; NP_001155898.1; NP_001155899.1

• Function
• Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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