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    Mouse Anti-TSC1 Recombinant Antibody (VS3-FY2908) (CAT#: VS3-FY2908)

    The anti-TSC1 antibody is a mouse recombinant monoclonal antibody that is designed to selectively bind to mouse TSC1 protein, a calculated molecular weight of the protein is about 129.8 kDa. The antibody can be utilized for detection of TSC1 by Western Blot (1/500-1/1000).

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    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line RH-30
    Figure 1 IF staining of human cell line RH-30
    (Immunofluorescent staining of human cell line RH-30 shows localization to cytosol & lipid droplets.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/74132/1666_F4_31_selected.jpg
    Figure 2 IF staining of human cell line U-251 MG
    Figure 2 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/if_selected.jpg
    Normal Tissue
    Figure 3 Lymph node
    Figure 3 Lymph node
    (Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_9_8.jpg
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_8_3.jpg
    Figure 6 Liver
    Figure 6 Liver
    (Cholangiocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_9_4.jpg
    Figure 7 Kidney
    Figure 7 Kidney
    (Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/11568/33733_A_8_5.jpg
    RNA Expression
    Figure 8 RNA cell line category: Low cell line specificity
    Figure 8 RNA cell line category: Low cell line specificity
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000165699-TSC1

    Specifications

    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Mouse TSC1
    • Species Reactivity
    • Mouse
    • Applications
    • Western Blot
    • Conjugate
    • Unconjugated, FITC
    • MW
    • The molecular weight of the target protein is approximately 129.8 kDa.
    • Related Disease
    • Tuberous Sclerosis 1 and Lymphangioleiomyomatosis

    Product Property

    • Clonality
    • Monoclonal Antibody
    • Format
    • Liquid
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • Western Blot: 1/500-1/1000

    Target

    • Alternative Names
    • TSC Complex Subunit 1; Tuberous Sclerosis 1 Protein; Hamartin; TSC; Tuberous Sclerosis 1; Tumor Suppressor; KIAA0243; LAM
    • Cellular Localization
    • Lysosome membrane
      Peripheral membrane protein
      Cytoplasm, cytosol
    • Post Translation Modifications
    • Phosphorylation at Ser-505 does not affect interaction with TSC2. (Q92574-TSC1_HUMAN)
      Modification sites at PhosphoSitePlus (Q92574)
      Modification sites at neXtProt (NX_Q92574)
      Glycosylation from GlyGen (Q92574) 2 sites, 1 O-linked glycan (2 sites)
    • Function
    • Non-catalytic component of the TSC-TBC complex, a multiprotein complex that acts as a negative regulator of the canonical mTORC1 complex, an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth.

    Recommended Products

    Secondary Antibody

    Isotype Control

    Related Resources

    • Related Signaling Pathways
    • Related Diseases

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "TSC1"

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    CAT Product Name Application Type
    MOB-3081z Mouse Anti-TSC1 Recombinant Antibody (clone 36H8) WB, FC, IHC Mouse IgG2b
    VS3-XY1551 Mouse Anti-TSC1 Recombinant Antibody (clone 357CT4.4.2) WB Mouse IgG2b

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