Mouse Anti-TSHR Recombinant Antibody (clone CS-17) (CAT#: HPAB-A1230-YJ)
This product is a Mouse antibody that recognizes TSHR.
Specific Inquiry
Agonist
Figure 1 The CS-17 Fab retains inverse agonist activity.
Chen, C. R., McLachlan, S. M., & Rapoport, B. (2008). Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology, 149(7), 3427-3434.
Inhib
Figure 2 The CS-17 Fab competes for binding of TSH to the TSHR.
Chen, C. R., McLachlan, S. M., & Rapoport, B. (2008). Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology, 149(7), 3427-3434.
Funs
Figure 3 The CS-17 IgG and Fab functional effects on TSHR mutations.
Chen, C. R., McLachlan, S. M., & Rapoport, B. (2008). Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology, 149(7), 3427-3434.
FC
Figure 4 Flow cytometric detection of TSHR mutants by mAb CS-17.
Chen, C. R., McLachlan, S. M., & Rapoport, B. (2009). A monoclonal antibody with thyrotropin (TSH) receptor inverse agonist and TSH antagonist activities binds to the receptor hinge region as well as to the leucine-rich domain. Endocrinology, 150(7), 3401-3408.
RIA
Figure 5 TSHR amino acids critical for CS-17 binding are distinct from contact residues in the TSH binding site.
Binding of 125I-TSH was determined in the presence of the indicated concentrations of unlabeled TSH.
Chen, C. R., McLachlan, S. M., & Rapoport, B. (2008). Identification of key amino acid residues in a thyrotropin receptor monoclonal antibody epitope provides insight into its inverse agonist and antagonist properties. Endocrinology, 149(7), 3427-3434.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TSHR
- Species Reactivity
- Human
- Clone
- CS-17
- Applications
- ELISA, FC, Agonist
Product Property
- Purification
- Protein A/G Purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- See the COA
- Buffer
- PBS
- Storage
- Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been reported for use in Enzyme-linked Immunosorbent Assay, Flow Cytometry, Agonist.
Target
- Alternative Names
- LGR3; CHNG1; hTSHR-I; thyrotropin receptor; TSH receptor; seven transmembrane helix receptor; thyrotropin receptor-I, hTSHR-I; Thyroid stimulating hormone receptor
- Gene ID
- 7253
- UniProt ID
- P16473
Related Resources
Autoimmune Thyroid Disease
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "TSHR"
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-353 | Mouse Anti-TSHR Recombinant Antibody (clone 3BD10); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| PSBL-730 | Human Anti-TSHR Recombinant Antibody (clone K1-70); scFv Fragment | Block | Human scFv |
| PSBW-172 | Human Anti-TSHR Recombinant Antibody (clone M22); scFv Fragment | WB | Human scFv |
| HPAB-0328CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (HPAB-0328CQ-S(P)) | ELISA, FC, FuncS | Mouse scFv |
| HPAB-0329CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (HPAB-0329CQ-S(P)) | ELISA, FC, FuncS, Agonist | Mouse scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-353 | Mouse Anti-TSHR Recombinant Antibody (clone 3BD10); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| PFBL-730 | Human Anti-TSHR Recombinant Antibody (clone K1-70); Fab Fragment | Block | Human Fab |
| FAMAB-0323CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody (clone 4G11); Fab Fragment | ELISA | Mouse Fab |
| FAMAB-0324CQ-F(E) | Mouse Anti-TSHR Recombinant Antibody (clone D2); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0367LY-F(E) | Human Anti-TSHR Recombinant Antibody (clone 5C9); Fab Fragment | Block, ELISA | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-722 | Human Anti-TSHR Recombinant Antibody (clone M22) | WB, IF, FuncS | Human IgG |
| PABW-172 | Recombinant Human Anti-TSHR Antibody (M22) | WB, ELISA, PK | IgG |
| FAMAB-0323CQ | Mouse Anti-TSHR Recombinant Antibody (clone 4G11) | ELISA, Inhib | Mouse IgM |
| FAMAB-0324CQ | Mouse Anti-TSHR Recombinant Antibody (clone D2) | ELISA | Mouse IgM |
| HPAB-0367LY | Human Anti-TSHR Recombinant Antibody (clone 5C9) | Block, ELISA | Human IgG1 |
Mouse Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-189CQ | Mouse Anti-TSHR Recombinant Antibody (TAB-189CQ) | ELISA, BL | Mouse IgG |
| TAB-190CQ | Mouse Anti-TSHR Recombinant Antibody (TAB-190CQ) | ELISA, BL | Mouse IgG |
| TAB-192CQ | Mouse Anti-TSHR Recombinant Antibody (TAB-192CQ) | ELISA, WB, Inhib | Mouse IgG |
| TAB-189CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-189CQ-S(P)) | ELISA, BL | Mouse scFv |
| TAB-190CQ-S(P) | Mouse Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-190CQ-S(P)) | ELISA, BL | Mouse scFv |
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-191CQ | Human Anti-TSHR Recombinant Antibody (TAB-191CQ) | ELISA, WB, Inhib | Human IgG |
| TAB-191CQ-S(P) | Human Anti-TSHR Recombinant Antibody; scFv Fragment (TAB-191CQ-S(P)) | ELISA, WB, Inhib | Human scFv |
| TAB-191CQ-F(E) | Human Anti-TSHR Recombinant Antibody; Fab Fragment (TAB-191CQ-F(E)) | ELISA, WB, Inhib | Human Fab |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2234CQ | Mouse Anti-TSHR Recombinant Antibody (clone 49) | Block, ELISA, ICC, IF, IP, WB | Mouse IgG1 |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for HPAB-A1230-YJ. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.