Mouse Anti-TTR Recombinant Antibody (clone 6F11B2) (CAT#: VS7-0425-WR1063)
This product is a mouse IgG1 antibody that binds to human TTR. The antibody 6F11B2 recognizes specific amino acid domain of human TTR (AA: 1-147). It can be used for FC assay.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
Figure 2 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
(Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
Figure 3 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
Figure 4 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
(Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
Figure 5 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
(Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
Figure 6 Liver
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
Figure 7 Pancreas
(Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
(Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
Figure 8 Kidney
(Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
(Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR
Specifications
- Immunogen
- Recombinant human TTR (AA: 1-147) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG1
- Specificity
- Human TTR
- Species Reactivity
- Human
- Clone
- 6F11B2
- Molecule Class
- Serum And Cerebrospinal Fluid Transport Protein,
- Applications
- FC
- Conjugate
- Unconjugated
- Related Disease
- Amyloidosis, hereditary systemic 1 (AMYLD1); Hyperthyroxinemia, dystransthyretinemic (DTTRH); Carpal tunnel syndrome 1 (CTS1)
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- TTR; TBPA; ATTR; HsT2651; Prealbumin; Carpal Tunnel Syndrome 1; Thyroxine-Binding Prealbumin; Epididymis Luminal Protein 111; CTS1; Prealbumin, Amyloidosis Type I; Transthyretin; PALB; HEL111; CTS
- Gene ID
- 7276
- UniProt ID
- P02766
- Long Name
- Transthyretin
- Cellular Localization
- Amyloid; Cytoplasm; Secreted
- Post Translation Modifications
- Gamma-carboxyglutamic acid; Glycoprotein; Phosphoprotein; Sulfation
- Protein Refseq
- NP_000362.1
- Function
- Hormone; Thyroid hormone
Recommended Products
Isotype Control
Secondary Antibody
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2498-sdAb | Recombinant Anti-human TTR VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| HPAB-0483-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0483-YJ-VHH) | ELISA | Camel VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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