Rabbit Anti-TTR Recombinant Antibody (clone R05-7D9)

CAT#: VS3-FY1850

This antibody performs western blot analysis of prealbumin in human tonsils and human placenta lysates. It is a rabbit recombinant monoclonal antibody that effectively detects human TTR. The antibody is recommended for detection of TTR protein by WB, IHC-P, IP.

Gene Expression Tested Data
Figure 1 IF staining of human cell line CACO-2 Figure 2 IHC staining of human hippocampus Figure 3 IHC staining of human liver Figure 4 IHC staining of human pancreas Figure 5 IHC staining of human kidney Figure 6 Liver Figure 7 Pancreas Figure 8 Kidney Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
Figure 1 Anti-TTR Antibody (VS3-FY1850) in WB.

Specifications

  • Immunogen
  • Synthetic peptide of human prealbumin
  • Host Species
  • Rabbit
  • Type
  • Rabbit IgG
  • Specificity
  • Human TTR
  • Species Reactivity
  • Human
  • Clone
  • R05-7D9
  • Applications
  • Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation
  • MW
  • The calculated weight of the target protein is approximately 16 kDa, while the observed molecular weight stands at 16 kDa.
  • Related Disease
  • Amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome

Product Property

  • Purification
  • Affinity Purified
  • Format
  • Liquid
  • Concentration
  • Please refer to the vial label for the specific concentration.
  • Storage
  • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Applications

  • Application Notes
  • Western Blot: 1/500-1/1000
    Immunohistochemistry: 1/50-1/100
    Immunoprecipitation: 1/20

Target

  • Alternative Names
  • Transthyretin; Prealbumin, Amyloidosis Type I; PALB; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin
  • Sequence Similarities
  • Belongs to the transthyretin family.
  • Cellular Localization
  • Amyloid, Cytoplasm, Secreted
  • Post Translation Modifications
  • Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.
  • Function
  • Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

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Secondary Antibody

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