Rabbit Anti-TTR Recombinant Antibody (VS13-YC1187) (CAT#: VS13-YC1187)
The Rabbit Anti-TTR Recombinant Antibody is specific for human and rat TTR. TTR encodes transthyretin, a thyroid hormone transport protein linked to amyloid deposition diseases due to gene mutations. The anti-TTR antibody can be used for Western blot (1/500-1/1000).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
Figure 2 IHC staining of human hippocampus
(Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
(Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
Figure 3 IHC staining of human liver
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
(Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
Figure 4 IHC staining of human pancreas
(Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
(Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
Figure 5 IHC staining of human kidney
(Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
(Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
Figure 6 Liver
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
(Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
Figure 7 Pancreas
(Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
(Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
Figure 8 Kidney
(Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
(Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR
Specifications
- Immunogen
- Recombinant human Prealbumin.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat TTR
- Species Reactivity
- Human, Rat
- Applications
- WB
- Conjugate
- NONE
- Related Disease
- Amyloidotic polyneuropathy, Euthyroid hyperthyroxinaemia, Amyloidotic vitreous opacities, Cardiomyopathy, Oculoleptomeningeal amyloidosis, Meningocerebrovascular amyloidosis and Carpal tunnel syndrome
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Target
- Alternative Names
- Transthyretin; Prealbumin, Amyloidosis Type I; PALB; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin;
- Gene ID
- 7276
- UniProt ID
- P02766
- Long Name
- Transthyretin
- Sequence Similarities
- Belongs to the transthyretin family.
- Cellular Localization
- Amyloid; Cytoplasm; Secreted
- Protein Refseq
- NP_000362.1
- Function
- Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2498-sdAb | Recombinant Anti-human TTR VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| HPAB-0483-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0483-YJ-VHH) | ELISA | Camel VHH |
| HPAB-0484-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0484-YJ-VHH) | ELISA | Camel VHH |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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