Mouse Anti-TTR Recombinant Antibody (VS3-FY2909)
CAT#: VS3-FY2909
The mouse anti-TTR recombinant monoclonal antibody has been developed to target human Prealbumin protein. This monoclonal antibody is suitable for conducting research on Hyperthyroxinemia, Dystransthyretinemic and Amyloidosis, Hereditary, Transthyretin-Related. The optimal dilution for this antibody is Western Blot (1/500-1/1000), Immunohistochemistry (1/50-1/100).
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
Normal Tissue
Figure 7 Pancreas
Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human TTR
- Species Reactivity
- Human
- Applications
- Western Blot, Immunohistochemistry
- Conjugate
- Unconjugated, FITC
- Related Disease
- Hyperthyroxinemia, Dystransthyretinemic and Amyloidosis, Hereditary, Transthyretin-Related
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunohistochemistry: 1/50-1/100
Target
- Alternative Names
- Transthyretin; Prealbumin, Amyloidosis Type I; PALB; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin
- Gene ID
- 7276
- UniProt ID
- P02766
- Sequence Similarities
- Belongs to the transthyretin family.
- Cellular Localization
- Amyloid, Cytoplasm, Secreted
- Post Translation Modifications
- Not glycosylated under normal conditions. Following unfolding, caused for example by variant AMYL-TTR 'Gly-38', the cryptic Asn-118 site is exposed and glycosylated by STT3B-containing OST complex, leading to its degradation by the ER-associated degradation (ERAD) pathway.
- Protein Refseq
- NP_000362.1
- Function
- Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TTR"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-2498-sdAb | Recombinant Anti-human TTR VHH Single Domain Antibody | ELISA, Neut, ICC, FC | Llama VHH |
| HPAB-0483-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0483-YJ-VHH) | ELISA | Camel VHH |
| HPAB-0484-YJ-VHH | Recombinant Camel Anti-TTR Single Domain Antibody (HPAB-0484-YJ-VHH) | ELISA | Camel VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBZ-128 | Mouse Anti-TTR Recombinant Antibody (clone 39-44); scFv Fragment | WB, Block | Mouse scFv |
| HPAB-0108-YC-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0108-YC-S(P)) | ELISA, FuncS | Human scFv |
| HPAB-0109-YC-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0109-YC-S(P)) | ELISA, WB, IP | Human scFv |
| HPAB-0110-YC-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0110-YC-S(P)) | ELISA, WB, IP | Human scFv |
| HPAB-0111-YC-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (HPAB-0111-YC-S(P)) | ELISA, WB, IP | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0423CL | Human Anti-TTR Recombinant Antibody (TAB-0423CL) | ELISA, DB, WB, IF | Human IgG |
| TAB-0423CL-S(P) | Human Anti-TTR Recombinant Antibody; scFv Fragment (TAB-0423CL-S(P)) | ELISA, DB, WB, IF | Human scFv |
| TAB-0423CL-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (TAB-0423CL-F(E)) | ELISA, DB, WB, IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-165CQ | Mouse Anti-TTR Recombinant Antibody (TAB-165CQ) | ELISA, WB | Mouse IgG1, κ |
| TAB-166CQ | Mouse Anti-TTR Recombinant Antibody (TAB-166CQ) | ELISA, WB | Mouse IgG1, κ |
| TAB-165CQ-S(P) | Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-165CQ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-166CQ-S(P) | Mouse Anti-TTR Recombinant Antibody; scFv Fragment (TAB-166CQ-S(P)) | ELISA, WB | Mouse scFv |
| TAB-165CQ-F(E) | Mouse Anti-TTR Recombinant Antibody; Fab Fragment (TAB-165CQ-F(E)) | ELISA, WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0600MZ | Chicken Anti-Transthyretin Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3717 | Rabbit Anti-TTR Recombinant Antibody (clone DS3717AB) | FC, ICC, IHC-P, IP, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0108-YC | Human Anti-TTR Recombinant Antibody (HPAB-0108-YC) | ELISA, FuncS | Human IgG |
| HPAB-0109-YC | Human Anti-TTR Recombinant Antibody (HPAB-0109-YC) | ELISA, WB, IP | Human IgG |
| HPAB-0110-YC | Human Anti-TTR Recombinant Antibody (HPAB-0110-YC) | ELISA, WB, IP | Human IgG |
| HPAB-0111-YC | Human Anti-TTR Recombinant Antibody (HPAB-0111-YC) | ELISA, WB, IP | Human IgG |
| MRO-1527-CN | Mouse Anti-TTR Recombinant Antibody (clone 3-E11) | WB, IF | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0108-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0108-YC-F(E)) | ELISA, FuncS | Human Fab |
| HPAB-0109-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0109-YC-F(E)) | ELISA, WB, IP | Human Fab |
| HPAB-0110-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0110-YC-F(E)) | ELISA, WB, IP | Human Fab |
| HPAB-0111-YC-F(E) | Human Anti-TTR Recombinant Antibody; Fab Fragment (HPAB-0111-YC-F(E)) | ELISA, WB, IP | Human Fab |
| HPAB-0642LY-F(E) | Mouse Anti-TTR Recombinant Antibody (clone 14G8); Fab Fragment | WB, FC, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY265 | AbPlus™ Anti-TTR Magnetic Beads (AD7F6) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2390 | Anti-TTR Immunohistochemistry Kit | IHC | |
| VS-0525-XY7597 | Anti-Mouse TTR Immunohistochemistry Kit | IHC | |
| VS-0525-XY7596 | Anti-Human TTR Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC321 | Recombinant Anti-TTR Eliminating Antibody, pH-Sensitive (VS-0625-YC321) | Antigen-Sweeping In Vivo. | Human IgG |
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