CytoStream™ Rabbit Anti-TUBB Recombinant Antibody (VS13-YC1191) (CAT#: VS13-YC1191)
The CytoStream™ Rabbit Anti-TUBB Recombinant Antibody is specific for human, mouse and rat TUBB. The TUBB gene encodes a beta-tubulin protein that forms a dimer with alpha-tubulin, acting as a structural component of microtubules. Mutations in this gene can lead to cortical dysplasia and complex brain malformations. The anti-TUBB antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5417/968_C12_1_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to microtubules.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5417/968_C12_1_selected.jpg
Figure 2 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to microtubules & cytokinetic bridge.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43640/1773_E7_6_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to microtubules & cytokinetic bridge.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43640/1773_E7_6_selected.jpg
Figure 3 IHC staining of human breast
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5417/ihc_selected.jpg
(Immunohistochemical staining of human breast shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5417/ihc_selected.jpg
Figure 4 Ovary.
(High expression in ovary)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_5_7_val_selected.jpg
(High expression in ovary)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_5_7_val_selected.jpg
Figure 5 Lymph node
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5417/19754_A_8_8.jpg
(Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/5417/19754_A_8_8.jpg
Figure 6 Colon
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_9_3.jpg
(Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_9_3.jpg
Figure 7 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_7_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_7_5.jpg
Figure 8 Testis
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_5_6.jpg
(Cells in seminiferous ducts Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/12406/31977_A_5_6.jpg
Figure 9 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196230-TUBB
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000196230-TUBB
Specifications
- Immunogen
- Recombinant human beta Tubulin, aa 308-357.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat TUBB
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, ICC, IF, IHC-P, FC
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/5000
Immunocytochemistry (ICC): 1/50
Immunohistochemistry-paraffin (IHC-P): 1/100-1/400
Flow cytometry (FC): 1/50
Target
- Alternative Names
- Tubulin Beta Class I; Tubulin, Beta Polypeptide; Tubulin Beta-5 Chain; TUBB5; Tubulin, Beta Class I; Class I Beta-Tubulin; Tubulin Beta-1 Chain; Tubulin Beta Chain; Beta Ib Tubulin;
- Gene ID
- 203068
- UniProt ID
- P07437
- Long Name
- Tubulin Beta Class I
- Sequence Similarities
- Belongs to the tubulin family.
- Cellular Localization
- Cytoplasm
- Protein Refseq
- NP_001280141.1; NP_001280142.1; NP_001280143.1
- Function
- Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "TUBB"
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
Epitope-Specific Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1767z | Mouse Anti-TUBB Recombinant Antibody (clone 28D11) | WB, ELISA, IF, IHC | Mouse IgG2b, κ |
| MOB-0911MZ | Recombinant Mouse Anti-Human TUBB Antibody (clone 48C) | ELISA, IHC-P, WB | Mouse antibody |
| ZG-0294U | Mouse Anti-TUBB Recombinant Antibody (clone 16E11D4) | ELISA, WB, IHC, IF, FC, IP | Mouse IgG2b |
| VS3-QX1193 | Mouse Anti-TUBB Recombinant Antibody (clone 10B7-1G4-7E1) | WB, IFIHC | Mouse IgG1 |
| VS3-QX1194 | Mouse Anti-TUBB Recombinant Antibody (clone 3D8-4E2-3F10) | WB, IHC, IP | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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